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Patient-Specific Simulations of Deep Brain Stimulation Electric Field with Aid of In-house Software ELMA
Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0002-6896-1452
Linköpings universitet, Institutionen för medicinsk teknik, Avdelningen för medicinsk teknik. Linköpings universitet, Tekniska fakulteten.ORCID-id: 0000-0002-0012-7867
2019 (engelsk)Inngår i: 2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), IEEE, 2019Konferansepaper, Publicerat paper (Fagfellevurdert)
Abstract [en]

Deep brain stimulation (DBS) is an established technique for reduction of symptoms in movement disorders. Finite element method (FEM) simulations of the electric field magnitude (EF) are useful for estimating the affected tissue around the DBS lead and this can help optimize the therapy. This paper describes how patient-specific FEM models can be set up with the aid of the Matlab-based in-house software tool ELMA. Electrode placement is determined from two coordinates in postoperative medical imaging and electric conductivity is assigned from preoperative magnetic resonance imaging (MRI) and patient-specific DBS data. Simulations are performed using the equation for steady currents in Comsol Multiphysics (CM). The simulated EF is superimposed on the preoperative MRI for evaluation of affected structures. The method is demonstrated with patient-specific simulations in the zona incerta and a globus pallidus example containing cysts with higher conductive which causes considerable distortion of the EF. The improved software modules and precise lead positioning simplifies and reduces the time for DBS EF modelling and simulation.

sted, utgiver, år, opplag, sider
IEEE, 2019.
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Identifikatorer
URN: urn:nbn:se:liu:diva-162290DOI: 10.1109/EMBC.2019.8856307OAI: oai:DiVA.org:liu-162290DiVA, id: diva2:1373278
Konferanse
The 41st International Engineering in Medicine and Biology Conference, Berlin, Germany, 23-27 July 2019
Forskningsfinansiär
Swedish Foundation for Strategic Research , BD15-0032Swedish Research Council, 2016-03564Knut and Alice Wallenberg Foundation, Seeing Organ FunctionTilgjengelig fra: 2019-11-26 Laget: 2019-11-26 Sist oppdatert: 2019-12-06bibliografisk kontrollert

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Johansson, Johannes DAlonso, FabiolaWårdell, Karin

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