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Role of ventral subiculum neuronal ensembles in incubation of oxycodone craving after electric barrier-induced voluntary abstinence
Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten. NIDA, MD 21224 USA.
NIDA, MD USA.
NIDA, MD 21224 USA.
NIDA, MD USA.
Vise andre og tillknytning
2023 (engelsk)Inngår i: Science Advances, E-ISSN 2375-2548, Vol. 9, nr 2, artikkel-id eadd8687Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

High relapse rate is a key feature of opioid addiction. In humans, abstinence is often voluntary due to negative consequences of opioid seeking. To mimic this human condition, we recently introduced a rat model of incubation of oxycodone craving after electric barrier-induced voluntary abstinence. Incubation of drug craving refers to time-dependent increases in drug seeking after cessation of drug self-administration. Here, we used the activity marker Fos, muscimol-baclofen (GABAa + GABAb receptor agonists) global inactivation, Daun020-selective inactivation of putative relapse-associated neuronal ensembles, and fluorescence-activated cell sorting of Fos-positive cells and quantitative polymerase chain reaction to demonstrate a key role of vSub neuronal ensembles in incubation of oxycodone craving after voluntary abstinence, but not homecage forced abstinence. We also used a longitudinal functional magnetic resonance imaging method and showed that functional connectivity changes in vSub-related circuits predict opioid relapse after abstinence induced by adverse consequences of opioid seeking.

sted, utgiver, år, opplag, sider
AMER ASSOC ADVANCEMENT SCIENCE , 2023. Vol. 9, nr 2, artikkel-id eadd8687
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Identifikatorer
URN: urn:nbn:se:liu:diva-191360DOI: 10.1126/sciadv.add8687ISI: 000911464300027PubMedID: 36630511OAI: oai:DiVA.org:liu-191360DiVA, id: diva2:1732576
Merknad

Funding Agencies|Intramural Research Program of the NIDA-NIH [ZIA-DA000434-22]; Swedish Research Council International Postdoc grant [2019-00658]

Tilgjengelig fra: 2023-01-31 Laget: 2023-01-31 Sist oppdatert: 2023-02-20

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