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Corticotropin-Releasing Hormone and Mast Cells in the Regulation of Mucosal Barrier Function in the Human Colon
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala.
2009 (engelsk)Inngår i: MOLECULAR STRUCTURE AND FUNCTION OF THE TIGHT JUNCTION: FROM BASIC MECHANISMS TO CLINICAL MANIFESTATIONS, ISSN 0077-8923, Vol. 1165, s. 206-210Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Corticotropin-releasing hormone (CRH) is an important neuro-endocrine mediator of the stress response. Local effects of CRH in the intestinal mucosa have become evident in recent years. We showed that CRH activates CRH receptor subtypes R1 and R2 on subepithelial mast cells, thereby inducing increased transcellular uptake of protein antigens in human colonic biopsies in Ussing chambers. Ongoing studies also implicate local cholinergic signaling in regulation of macromolecular permeability in the human colon. Since increased uptake of antigenic molecules is associated with mucosal inflammation, our findings may have implications for understanding stress-related intestinal disorders.

sted, utgiver, år, opplag, sider
2009. Vol. 1165, s. 206-210
Emneord [en]
CRH receptor; Ussing chamber; stress; electron microscopy; transcytosis; intestinal mucosa
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-20216DOI: 10.1111/j.1749-6632.2009.04030.xOAI: oai:DiVA.org:liu-20216DiVA, id: diva2:233802
Tilgjengelig fra: 2009-09-02 Laget: 2009-08-31 Sist oppdatert: 2009-09-02

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