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Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells
KI, Stockolm.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Klinisk farmakologi.ORCID-id: 0000-0002-2809-7591
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för medicin och vård, Klinisk farmakologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk farmakologi.
KI, Stockholm.
2006 (engelsk)Inngår i: Nucleosides, Nucleotides & Nucleic Acids, ISSN 1525-7770, E-ISSN 1532-2335, Vol. 25, nr 9-11, s. 1039-1044Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In order to better understand the mechanisms of resistance to thiopurines, we studied two sublines of the MOLT4 T-lymphoblastic leukemia cell line, resistant to 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG). We found that the underlying mechanism of resistance in both resistant cell lines was a markedly reduction in initial transport of 6-MP (3- and 5-fold, respectively, in 6-MP- and 6-TG-resistant cells). No significant alteration of activities of hypoxanthine-guanine phosphoribosyl transferase, thiopurine methyltransferase or inosine monophosphate dehydrogenase, the key enzymes involved in the metabolism of thiopurines was detected. We conclude that defected initial transport of thiopurines by cells may very well explain their resistance to these drugs. Copyright © Taylor & Francis Group, LLC.

sted, utgiver, år, opplag, sider
2006. Vol. 25, nr 9-11, s. 1039-1044
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URN: urn:nbn:se:liu:diva-36780DOI: 10.1080/15257770600890848Lokal ID: 32533OAI: oai:DiVA.org:liu-36780DiVA, id: diva2:257629
Tilgjengelig fra: 2009-10-10 Laget: 2009-10-10 Sist oppdatert: 2017-12-13

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