liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Alternative splicing and its regulation under normal and abnormal conditions
Linköpings universitet, Institutionen för fysik, kemi och biologi.
2010 (engelsk)Independent thesis Basic level (degree of Bachelor), 10 poäng / 15 hpOppgave
Abstract [en]

During the maturation of pre-mRNA introns are removed and exons are spliced together, to form a primary transcript, a reaction that is catalyzed by the spliceosome. Alternative splicing is a complex reaction that mainly utilizes one of four mechanisms; exon skipping, 5’ splice site choice, 3’ splice site choice and intron retention. To achieve accurate splicing four sequence elements are essential, two of which are located in the splice sites themselves; 5’ splice sites and 3’ splice sites, but also the polypyrimidine tract and the branch point sequence. Alternative splicing can be regulated by histone or chromatin modulations, siRNA, transcription efficiency and various proteins, many of which belong to either the SR protein family or the hnRNP family of proteins. SR proteins usually promote exon inclusion, while hnRNP proteins usually promote exon skipping. There are also regulatory elements that are called exonic splicing enhancers or silencers depending on if they promote or inhibit the inclusion of the exon they reside in. These elements also exist in introns and are then called intronic splicing enhancers or silencers. The enhancer elements are most commonly targeted by SR proteins and the silencer elements are usually targeted by hnRNP proteins. This paper will mainly focus on the regulation of alternative splicing and the role of alternative splicing under abnormal conditions, such as when mutations cause disease.

sted, utgiver, år, opplag, sider
2010. , s. 24
Emneord [en]
Alternative splicing, ESE, ESS, hnRNP proteins, ISE, ISS, Regulation, Spliceosome, SR proteins
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-56899ISRN: LITH-IFM-Ex--10/2350--SEOAI: oai:DiVA.org:liu-56899DiVA, id: diva2:322875
Presentation
, Linköpings universitet, Linköping (engelsk)
Uppsök
Life Earth Science
Examiner
Tilgjengelig fra: 2010-06-10 Laget: 2010-06-08 Sist oppdatert: 2011-05-18bibliografisk kontrollert

Open Access i DiVA

fulltekst(689 kB)816 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 689 kBChecksum SHA-512
88f7b95857b0744b153ee8b453950e5de944a21e6773f87739e05ca73971af07b4f8aeb9630ba23d1084d448d3f812bb646877a573b00177a3d6034568d69abd
Type fulltextMimetype application/pdf

Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 816 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

urn-nbn

Altmetric

urn-nbn
Totalt: 422 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf