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The intestinal barrier and its regulation by neuroimmune factors
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Kirurgi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Kirurgi- och onkologicentrum, Kirurgiska kliniken i Östergötland med verksamhet i Linköping, Norrköping och Motala.
2010 (engelsk)Inngår i: Neurogastroenterology and Motility, ISSN 1350-1925, E-ISSN 1365-2982, Vol. 22, nr 7, s. 718-733Artikkel, forskningsoversikt (Fagfellevurdert) Published
Abstract [en]

Background The ability to control uptake across the mucosa and protect from damage of harmful substances from the lumen is defined as intestinal barrier function. A disturbed barrier dysfunction has been described in many human diseases and animal models, for example, inflammatory bowel disease, irritable bowel syndrome, and intestinal hypersensitivity. In most diseases and models, alterations are seen both of the paracellular pathway, via the tight junctions, and of the transcellular routes, via different types of endocytosis. Recent studies of pathogenic mechanisms have demonstrated the important role of neuroimmune interaction with the epithelial cells in the regulation of barrier function. Neural impulses from extrinsic vagal and/or sympathetic efferent fibers or intrinsic enteric nerves influence mucosal barrier function via direct effects on epithelial cells or via interaction with immune cells. For example, by nerve-mediated activation by corticotropin-releasing hormone or cholinergic pathways, mucosal mast cells release a range of mediators with effects on transcellular, and/or paracellular permeability (for example, tryptase, TNF-alpha, nerve growth factor, and interleukins). Purpose In this review, we discuss current physiological and pathophysiological aspects of the intestinal barrier and, in particular, its regulation by neuroimmune factors.

sted, utgiver, år, opplag, sider
Blackwell Publishing Ltd , 2010. Vol. 22, nr 7, s. 718-733
Emneord [en]
corticotropin-releasing hormone; enteric nerves; mast cell; permeability; stress
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-58363DOI: 10.1111/j.1365-2982.2010.01498.xISI: 000278525200002OAI: oai:DiVA.org:liu-58363DiVA, id: diva2:343330
Tilgjengelig fra: 2010-08-13 Laget: 2010-08-11 Sist oppdatert: 2017-12-12

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