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HMGB1-derived peptide acts as adjuvant inducing immune responses to peptide and protein antigen
University of California.
University of Sao Paulo.
University of California.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Molekylär virologi. Linköpings universitet, Hälsouniversitetet.
Vise andre og tillknytning
2010 (engelsk)Inngår i: VACCINE, ISSN 0264-410X, Vol. 28, nr 47, s. 7556-7562Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

There is a need for new adjuvants that will induce immune responses to subunit vaccines. We show that a short peptide, named Hp91, whose sequence corresponds to an area within the endogenous molecule high mobility group box (HMGB1) protein 1 potentiates cellular immune responses to peptide antigen and cellular and humoral immune responses to protein antigen in vivo. Hp91 promoted the in vivo production of the immunomodulatory cytokines, IFN-gamma, TNF-alpha, IL-6, and IL-12 (p70), as well as antigen-specific activation of CD8+ T cells. These results demonstrate the ability of a short immunostimulatory peptide to serve as an adjuvant for subunit vaccines.

sted, utgiver, år, opplag, sider
Elsevier Science B.V., Amsterdam. , 2010. Vol. 28, nr 47, s. 7556-7562
Emneord [en]
HMGB-1 peptides, Adjuvants, Vaccine, Immunotherapy, Dendritic cells
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-63143DOI: 10.1016/j.vaccine.2010.08.054ISI: 000284435500017OAI: oai:DiVA.org:liu-63143DiVA, id: diva2:376675
Tilgjengelig fra: 2010-12-13 Laget: 2010-12-13 Sist oppdatert: 2014-06-04

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