liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
beta 2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity
Scripps Research Institute.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Molekylär och immunologisk patologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk patologi och klinisk genetik.
Scripps Research Institute.
Scripps Research Institute.
Vise andre og tillknytning
2011 (engelsk)Inngår i: JOURNAL OF IMMUNOTOXICOLOGY, ISSN 1547-691X, Vol. 8, nr 3, s. 228-237Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

ercury exposure in both humans and mice is associated with features of systemic autoimmunity. Murine HgCl(2)-induced autoimmunity (mHgIA) requires MHC Class II, CD4(+) T-cells, co-stimulatory molecules, and interferon-gamma (IFN-gamma), similar to spontaneous models of systemic lupus erythematosus (SLE). beta(2)-microglobulin (B2m) is required for functional MHC Class I molecules and the neonatal F(c) receptor (F(c)Rn). Deficiency of B2m in lupus-prone strains is consistently associated with reduced IgG levels, but with variable effects on other manifestations. Herein, we examined the role of B2m in mHgIA and show that in the absence of B2m, mercury-exposed mice failed to exhibit hypergammaglobulinemia, had reduced anti-nucleolar autoantibodies (ANoA), and had a lower incidence of immune complex deposits in splenic blood vessels, whereas IgG anti-chromatin autoantibodies and renal immune deposits were largely unaffected. Subclass analysis of the IgG anti-chromatin, however, revealed a significant reduction in the IgG(1) subtype. Examination of IFN gamma, IL-4, and IL-2 in exposed skin, draining lymph nodes, and spleen following mercury exposure showed reduced IL-4 in the spleen and skin in B2m-deficient mice, consistent with the lower IgG(1) anti-chromatin levels, and reduced IFN-gamma expression in the skin. These findings demonstrate how a single genetic alteration can partially but significantly modify the clinical manifestations of systemic autoimmunity induced by exposure to xenobiotics.

sted, utgiver, år, opplag, sider
Informa Healthcare , 2011. Vol. 8, nr 3, s. 228-237
Emneord [en]
Autoantibodies, autoimmunity, cytokines, immune deposits, mercury, beta 2-microglobulin, mouse, xenobiotic
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-69991DOI: 10.3109/1547691X.2011.583614ISI: 000293239100006OAI: oai:DiVA.org:liu-69991DiVA, id: diva2:433991
Tilgjengelig fra: 2011-08-12 Laget: 2011-08-12 Sist oppdatert: 2011-08-12

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Hultman, Per

Søk i DiVA

Av forfatter/redaktør
Hultman, Per
Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 61 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf