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Sleep disordered breathing in community dwelling elderly: Associations with cardiovascular disease, impaired systolic function, and mortality after a six-year follow-up
Linköpings universitet, Institutionen för medicin och hälsa, Kardiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Kardiologiska kliniken US.ORCID-id: 0000-0001-7431-2873
Linköpings universitet, Institutionen för medicin och hälsa, Kardiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Kardiologiska kliniken US.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk neurofysiologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk neurofysiologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Sinnescentrum, Neurofysiologiska kliniken US.
Vise andre og tillknytning
2011 (engelsk)Inngår i: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 12, nr 8, s. 748-753Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Introduction: Sleep disordered breathing (SDB), cardiovascular disease (CVD) and impaired cardiac function are common in elderly people. We investigated the association of SDB and mortality in a community dwelling elderly population, considering CVD and objectively measured impaired cardiac function have been poorly studied thus far. less thanbrgreater than less thanbrgreater thanAim: To investigate whether SDB is a factor that affects mortality in elderly people, with a focus on those with CVD and/or signs of impaired cardiac function. less thanbrgreater than less thanbrgreater thanMethods: A prospective cohort design was used and 331 community dwelling elderly aged 71-87 years underwent one-night polygraphic recordings in the subjects homes. CVD and systolic function were objectively established. Mortality data were collected after 6 years. less thanbrgreater than less thanbrgreater thanResults: in the total population there were no significant associations between mortality and SOB. In those with CVD and impaired systolic function, as measured by NT-proBNP, oxygen desaturation index (ODI) andgt;= 10 was associated with mortality. The hazard ratio of 3.0 (Cl 95% 1.1-8.6, p = 0.03) remained statistically significant after adjustments for age, gender, diabetes and plasma values of NT-proBNP. less thanbrgreater than less thanbrgreater thanConclusion: SOB in community dwelling elderly has no overall association to mortality irrespective of degree of SDB. However, hypoxic events (i.e., ODI andgt;= 10) were associated with mortality in the group who had CVD in combination with impaired systolic function.

sted, utgiver, år, opplag, sider
Elsevier , 2011. Vol. 12, nr 8, s. 748-753
Emneord [en]
Sleep apnea syndromes, Aging, Elderly persons, Mortality, Cardiovascular disease, Cardiac function
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-71805DOI: 10.1016/j.sleep.2011.03.012ISI: 000295764800003OAI: oai:DiVA.org:liu-71805DiVA, id: diva2:453985
Merknad
Funding Agencies|Health Research Council in the Southeast of Sweden|F2004-233|Lisa and Johan Gronbergs foundation||Tilgjengelig fra: 2011-11-04 Laget: 2011-11-04 Sist oppdatert: 2017-12-08

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Johansson, PeterAlehagen, UrbanUlander, MartinSvanborg, EvaDahlström, UlfBroström, Anders

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