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Ki-67 expression in relation to clinicopathological variables and prognosis in colorectal adenocarcinomas
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Onkologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Onkologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Onkologiska kliniken US.
1997 (engelsk)Inngår i: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS), ISSN 0903-4641, E-ISSN 1600-0463, Vol. 105, nr 9, s. 730-734Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Ki-67 is a protein associated with cell proliferation which is expressed in all phases of the cell cycle except Go. In the present study, Ki-67 expression in 255 human colorectal adenocarcinomas was examined using immunohistochemistry with the monoclonal antibody MIB-1. One hundred and fifty-seven (62%) cases had more than 50% positive tumour cells and 98 (38%) cases less than 50%. The tumours showed a wide range of Ki-67 expression, from 13% to 90%, which indicated a variation in proliferative activity. There was no significant relationship between Ki-67 expression and sex, age, tumour location, Dukes' stage, growth pattern, differentiation, DNA content, S-phase fraction or survival (p > 0.05). In conclusion, the proliferative activity as measured by Ki-67 antibody was not related to clinicopathology and prognosis in colorectal cancer.

sted, utgiver, år, opplag, sider
Wiley-Blackwell , 1997. Vol. 105, nr 9, s. 730-734
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URN: urn:nbn:se:liu:diva-72301DOI: 10.1111/j.1699-0463.1997.tb05078.xISI: A1997XZ51500011PubMedID: 9350218OAI: oai:DiVA.org:liu-72301DiVA, id: diva2:458957
Tilgjengelig fra: 2011-11-24 Laget: 2011-11-24 Sist oppdatert: 2017-12-08

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