liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Low diversity of the gut microbiota in infants with atopic eczema
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
Department of Preparedness, Swedish Institute for Communicable Disease Control, Solna, Sweden.
Science for Life Laboratory, School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, and the School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Vise andre og tillknytning
2012 (engelsk)Inngår i: Journal of Allergy and Clinical Immunology, ISSN 0091-6749, E-ISSN 1097-6825, Vol. 129, nr 2, s. 434-440Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background

It is debated whether a low total diversity of the gut microbiota in early childhood is more important than an altered prevalence of particular bacterial species for the increasing incidence of allergic disease. The advent of powerful, cultivation-free molecular methods makes it possible to characterize the total microbiome down to the genus level in large cohorts.

Objective

We sought to assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to atopic eczema development.

Methods

Microbial diversity and composition were analyzed with barcoded 16S rDNA 454-pyrosequencing in stool samples at 1 week, 1 month, and 12 months of age in 20 infants with IgE-associated eczema and 20 infants without any allergic manifestation until 2 years of age (ClinicalTrials.gov ID NCT01285830).

Results

Infants with IgE-associated eczema had a lower diversity of the total microbiota at 1 month (P = .004) and a lower diversity of the bacterial phylum Bacteroidetes and the genus Bacteroides at 1 month (P = .02 and P = .01) and the phylum Proteobacteria at 12 months of age (P = .02). The microbiota was less uniform at 1 month than at 12 months of age, with a high interindividual variability. At 12 months, when the microbiota had stabilized, Proteobacteria, comprising gram-negative organisms, were more abundant in infants without allergic manifestation (Empirical Analysis of Digital Gene Expression in R [edgeR] test: P = .008, q = 0.02).

Conclusion

Low intestinal microbial diversity during the first month of life was associated with subsequent atopic eczema.

sted, utgiver, år, opplag, sider
Elsevier , 2012. Vol. 129, nr 2, s. 434-440
Emneord [en]
Allergic disease, Bacteroides species, diversity, eczema, hygiene hypothesis, infant, microbiota, molecular microbiology, pyrosequencing, Sutterella species
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-75901DOI: 10.1016/j.jaci.2011.10.025ISI: 000299951700021PubMedID: 22153774OAI: oai:DiVA.org:liu-75901DiVA, id: diva2:510548
Merknad

Funding Agencies|BioGaia AB, Stockholm, Sweden||Ekhaga Foundation, the Heart and Lung foundation||Research Council for the South-East Sweden|F2000-106|Olle Engqvist Foundation||Swedish Asthma and Allergy Association||Swedish Research Council||University Hospital of Linkoping||Soderberg Foundation||Vardal Foundation for Health Care Science and Allergy Research, Sweden||BioGaia AB||

Tilgjengelig fra: 2012-03-16 Laget: 2012-03-16 Sist oppdatert: 2017-12-07

Open Access i DiVA

fulltext(348 kB)1233 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 348 kBChecksum SHA-512
5f62325df6e323abab26fd73f6332224431f85362634829b3e281d30729919b859fc173f5949056c022236ae956dfc5a0e5c6b552f1d4f1b2afc53d5932e9702
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Abrahamsson, ThomasJenmalm, Maria

Søk i DiVA

Av forfatter/redaktør
Abrahamsson, ThomasJenmalm, Maria
Av organisasjonen
I samme tidsskrift
Journal of Allergy and Clinical Immunology

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 1233 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 544 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf