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Preparation of amyloidlike fibrils containing magnetic iron oxide nanoparticles: Effect of protein aggregation on proton relaxivity
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Molekylär ytfysik och nanovetenskap. Linköpings universitet, Tekniska fakulteten.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biomolekylär och Organisk Elektronik. Linköpings universitet, Tekniska fakulteten.
2012 (engelsk)Inngår i: Biochemical and Biophysical Research Communications - BBRC, ISSN 0006-291X, E-ISSN 1090-2104, Vol. 419, nr 4, s. 682-686Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

A method to prepare amyloid-like fibrils functionalized with magnetic nanoparticles has been developed. The amyloid-like fibrils are prepared in a two step procedure, where insulin and magnetic nanoparticles are mixed simply by grinding in the solid state, resulting in a water soluble hybrid material. When the hybrid material is heated in aqueous acid, the insulin/nanoparticle hybrid material self assembles to form amyloid-like fibrils incorporating the magnetic nanoparticles. This results in magnetically labeled amyloid-like fibrils which has been characterized by Transmission Electron Microscopy (TEM) and electron tomography. The influence of the aggregation process on proton relaxivity is investigated. The prepared materials have potential uses in a range of bio-imaging applications.

sted, utgiver, år, opplag, sider
Elsevier , 2012. Vol. 419, nr 4, s. 682-686
Emneord [en]
Amyloid fibrils, Magnetic nanoparticles, Electron tomography, Self-assembly, Proton relaxation
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-76954DOI: 10.1016/j.bbrc.2012.02.077ISI: 000302335800016OAI: oai:DiVA.org:liu-76954DiVA, id: diva2:524357
Merknad

Funding Agencies|Swedish Research Council (VR)||VINNOVA||Carl Trygger Foundation|10:388|Swedish Royal Academy of Sciences (INA)||Lars Hiertas foundation||

Tilgjengelig fra: 2012-05-02 Laget: 2012-04-27 Sist oppdatert: 2017-12-07

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Andersson, ViktorSkoglund, CarolineUvdal, KajsaSolin, Niclas

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