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Investigation of signal fading in lithium formate EPR dosimeters using a new sensitive method
Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för radiologiska vetenskaper. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US.ORCID-id: 0000-0003-0209-498X
Linköpings universitet, Institutionen för medicin och hälsa, Medicinsk radiofysik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Radiofysikavdelningen US. Swedish Radiation Safety Authority, Stockholm, Sweden .
Vise andre og tillknytning
2012 (engelsk)Inngår i: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 57, nr 8, s. 2209-2217Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The aim of this study was to investigate signal fading in lithium formate electron paramagnetic resonance (EPR) dosimeters used for clinical applications in radiotherapy. A new experimental method for determination of signal fading, designed to resolve small changes in signal from slowly decaying unstable radicals, was used. Possible signal fading in lithium formate due to different storage temperatures was also tested. Air humidity was kept at a constant level of 33% throughout the experiments. The conclusion drawn from the investigations was that the EPR signal from lithium formate is stable during at least 1 month after irradiation and is not sensitive to variations in storage temperature andlt;40 degrees C when kept at a relative air humidity of 33%. This makes lithium formate a suitable dosimeter for transfer dosimetry in clinical audits.

sted, utgiver, år, opplag, sider
Institute of Physics (IOP), 2012. Vol. 57, nr 8, s. 2209-2217
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-77095DOI: 10.1088/0031-9155/57/8/2209ISI: 000302567100008PubMedID: 22456424OAI: oai:DiVA.org:liu-77095DiVA, id: diva2:524959
Merknad

Funding Agencies|Swedish Cancer foundation (CF)|100443|FORSS|86231|

Tilgjengelig fra: 2012-05-04 Laget: 2012-05-04 Sist oppdatert: 2017-12-07bibliografisk kontrollert
Inngår i avhandling
1. Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
Åpne denne publikasjonen i ny fane eller vindu >>Lithium formate EPR dosimetry for accurate measurements of absorbed dose in radiotherapy
2014 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Lithium formate has shown to be a material with properties suitable for electron paramagnetic resonance (EPR) dosimetry, among them up to 7 times higher sensitivity compared to alanine, which is a well-established EPR detector material for dose determinations in radiotherapy.

The aim of this thesis was to further investigate the properties of lithium formate and develop the dosimetry system towards applications in radiotherapy. The intrinsic efficiency for energies of relevance to brachytherapy and the signal stability were investigated. The dosimetry system was expanded to include a smaller dosimeter model, suitable for measurements in dose gradient regions. An individual sensitivity correction method was applied to the smaller dosimeters to be able to perform dose determinations with the same precision as for the larger ones. EPR dosimetry in general is time consuming and effort was spent to optimize the signal readout procedure regarding measurement time and measurement precision.

The system was applied in two clinical applications chosen for their high demands on the dosimetry system: 1) a dosimetry audit for external photon beam therapy and 2) dose verification measurements around a low energy HDR brachytherapy source.

The conclusions drawn from this thesis were: dose determinations can be performed with a standard uncertainty of 1.8-2.5% using both the original size dosimeters and the new developed smaller ones. The dosimetry system is robust and useful for applications when high measurement precision and accuracy is prioritized. It is a good candidate for dosimetry audits, both in external beam therapy and brachytherapy.

sted, utgiver, år, opplag, sider
Linköping: Linköping University Electronic Press, 2014. s. 51
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1417
HSV kategori
Identifikatorer
urn:nbn:se:liu:diva-111091 (URN)10.3384/diss.diva-111091 (DOI)978-91-7519-246-8 (ISBN)
Disputas
2014-11-06, Eken, ingång 65, plan 9, Campus US, Linköpings universitet, Linköping, 09:00 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2014-10-07 Laget: 2014-10-07 Sist oppdatert: 2015-03-20bibliografisk kontrollert

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