liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
LTBP-2 confers pleiotropic suppression and promotes dormancy in a growth factor permissive microenvironment in nasopharyngeal carcinoma
Hong Kong University of Science and Technology, Peoples R China .
University of Hong Kong, Peoples R China .
University of Hong Kong, Peoples R China .
University of Helsinki, Finland University of Helsinki, Finland .
Vise andre og tillknytning
2012 (engelsk)Inngår i: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 325, nr 1, s. 89-98Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment.

sted, utgiver, år, opplag, sider
Elsevier , 2012. Vol. 325, nr 1, s. 89-98
Emneord [en]
Latent transforming growth factor beta binding protein 2 (LTBP-2), Nasopharyngeal carcinoma (NPC), Anti-angiogenesis, Tumor suppression, Tumor cell dormancy, Metastatic growth
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-84878DOI: 10.1016/j.canlet.2012.06.005ISI: 000308781600011OAI: oai:DiVA.org:liu-84878DiVA, id: diva2:564145
Merknad

Funding Agencies|University Grants Council|AoE/M-06/08|Finnish Cancer Foundation||Swedish Cancer Society||Swedish Research Council||Swedish Institute||Karolinska Institute||

Tilgjengelig fra: 2012-11-01 Laget: 2012-10-26 Sist oppdatert: 2017-12-07

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst
Av organisasjonen
I samme tidsskrift
Cancer Letters

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 110 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf