liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Residual beta cell function at diagnosis of type 1 diabetes in children and adolescents varies with gender and season
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Pediatrik. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
Queen Silvia Children's Hospital, Sweden.
Lund University Hospital, Sweden.
Queen Silvia Children's Hospital, Sweden.
Vise andre og tillknytning
2013 (engelsk)Inngår i: Diabetes/Metabolism Research Reviews, ISSN 1520-7552, E-ISSN 1520-7560, Vol. 29, nr 1, s. 85-89Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background

There are seasonal variations and gender differences in incidence of type 1 diabetes (T1D), metabolic control and responses to immune interventions at onset of the disease.

We hypothesized that there are seasonal and gender differences in residual insulin secretion already at diagnosis of T1D.

Methods

In 2005, a national study, the Better Diabetes Diagnosis, was started to classify all newly diagnosed children and adolescents with diabetes. About 95% (3824/4017) of the patients were classified as T1D, and our analyses are based on the patients with T1D.

Results

C-peptide was lower in younger children, 0–10 years of age (0.23 ± 0.20 nmol/L) than in older children, 11–18 years of age (0.34 ± 0.28 nmol/L) (p  < 0.000 ). There was a seasonal variation in non-fasting serum C-peptide, significantly correlated to the seasonal variation of diagnosis (p < 0.01). Most children were diagnosed in January, February and March as well as in October when C-peptide was highest, whereas fewer patients were diagnosed in April and May when serum C-peptide was significantly lower (p < 0.01). The seasonal variation of C-peptide was more pronounced in boys than in girls (p < 0.000 and p < 0.01, respectively). Girls had higher C-peptide than boys (p < 0.05), especially in early puberty.

Conclusions

Both seasonal and gender differences in residual beta cell function exist already at diagnosis of T1D. These observations have consequences for treatment and for randomizing patients in immune intervention clinical trials.

sted, utgiver, år, opplag, sider
John Wiley and Sons , 2013. Vol. 29, nr 1, s. 85-89
Emneord [en]
C-peptide, children, type 1 diabetes, seasonal variation, gender, immune intervention
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-90084DOI: 10.1002/dmrr.2365ISI: 000313546000013OAI: oai:DiVA.org:liu-90084DiVA, id: diva2:612411
Merknad

Funding Agencies|Swedish Child Diabetes Foundation (Barndiabetesfonden)||

Tilgjengelig fra: 2013-04-10 Laget: 2013-03-19 Sist oppdatert: 2017-12-06bibliografisk kontrollert

Open Access i DiVA

fulltext(447 kB)495 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 447 kBChecksum SHA-512
4d171aa5897253f796d14203ce6db8a095a36a8a23cbabcec94e35f5b928adb1f59a1d6bca8f57bfe1992742c070ec0d9f7763b47f9ebc791bb4de3ee4c92af8
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekst

Person

Samuelsson, UlfLudvigsson, Johnny

Søk i DiVA

Av forfatter/redaktør
Samuelsson, UlfLudvigsson, Johnny
Av organisasjonen
I samme tidsskrift
Diabetes/Metabolism Research Reviews

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 496 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 277 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf