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Leptin and adiponectin in cord blood from children of normal weight, overweight and obese mothers
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Obstetrik och gynekologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Kvinnokliniken i Linköping.
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2013 (engelsk)Inngår i: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 102, nr 6, s. 620-624Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aim To study cord blood concentrations of adiponectin and leptin in children born by normal weight, overweight and obese mothers and to study these parameters in relation to a weight gain intervention programme for obese mothers. Methods Ten millilitre cord blood was collected and analysed for leptin and adiponectin concentrations in children with gestational age andgt;37weeks born by 60 normal weight, 45 overweight and 145 obese mothers. 82 obese mothers took part in a weight gain intervention programme. Results Concentrations of leptin and adiponectin were higher in cord blood from children of overweight and obese mothers compared with children of normal weight mothers (leptin: Md 13.2, 30, 3 and 90.2ng/mL respectively, pandlt;0.001; adiponectin 35.9, 205.4, 213.8ng/L pandlt;0.001). No differences were found between overweight and obese mothers. The weight gain intervention programme for obese pregnant women had significant effects on the weight gain during pregnancy but had no effects on cord blood serum concentrations of leptin and adiponectin. Conclusion Cord blood leptin and adiponectin concentrations were higher in children born by overweight or obese women compared with children of normal weight mothers. A weight gain intervention programme for obese pregnant women did not affect these results. Intrauterine exposition to high concentrations of leptin and adiponectin may play a role in weight development later in life.

sted, utgiver, år, opplag, sider
Wiley-Blackwell , 2013. Vol. 102, nr 6, s. 620-624
Emneord [en]
Adiponectin, Leptin, Obesity, Umbilical cord
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Identifikatorer
URN: urn:nbn:se:liu:diva-94318DOI: 10.1111/apa.12202ISI: 000318562500027OAI: oai:DiVA.org:liu-94318DiVA, id: diva2:632002
Merknad

Funding Agencies|Health Research Council of the Southeast of Sweden||ALF, County Council of Ostergotland||

Tilgjengelig fra: 2013-06-24 Laget: 2013-06-24 Sist oppdatert: 2019-06-28

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Brynhildsen, JanSydsjö, GunillaBlomberg, MarieClaesson, Ing-MarieTheodorsson, ElvarNyström, Fredrik H.Sydsjö, AdamJosefsson, Ann

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