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Intraepithelial lymphocyte distribution differs between the bulb and the second part of duodenum
Oskarshamn Hospital, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Klinisk immunologi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Diagnostikcentrum, Klinisk immunologi och transfusionsmedicin.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för inflammationsmedicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Magtarmmedicinska kliniken.
2013 (engelsk)Inngår i: BMC Gastroenterology, ISSN 1471-230X, E-ISSN 1471-230X, Vol. 13Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background

Evaluation of intraepithelial duodenal lymphocytosis (IDL) is important in celiac disease (CD). There is no established cut-off value for increased number of IELs in the bulb.

We therefore investigated the relation between IEL counts in the bulb and duodenal specimens in non-celiac subjects.

Methods

The number of CD3+ IELs was determined in specimens from the second part of the duodenum and from the bulb in 34 non-celiac subjects. The numbers of IELs in the villus tip and sides were counted and the quotient tip/side was calculated. HLA DQ2/DQ8 and serum antibodies against transglutaminase were analysed.

Results

The mean number of IELs per 100 enterocytes (95% CI) in specimens was 14.7 (11.8-17.6) in the bulb, and 21.2 (17.0-25.5) in the second part of the duodenum (p<0.01). There was no difference in IEL count or distribution comparing patients carrying or lacking HLA DQ2/DQ8.

Conclusions

IEL count in non-celiac, HLA DQ2/DQ8 positive or negative patients is significantly lower in the bulb than in the second part of the duodenum. These findings implicate that the site of biopsy should be taken into account when considering duodenal lymphocytosis.

sted, utgiver, år, opplag, sider
BioMed Central , 2013. Vol. 13
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-96711DOI: 10.1186/1471-230X-13-111ISI: 000322132500001OAI: oai:DiVA.org:liu-96711DiVA, id: diva2:642970
Merknad

Funding Agencies|Medical Research Council of Southeast Sweden||

Tilgjengelig fra: 2013-08-23 Laget: 2013-08-23 Sist oppdatert: 2017-12-06

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Ignatova, SimoneDahle, CharlotteStröm, Magnus

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