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ABCB1 gene polymorphisms are associated with suicide in forensic autopsies
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Klinisk farmakologi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för läkemedelsforskning. Linköpings universitet, Hälsouniversitetet.
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2013 (engelsk)Inngår i: Pharmacogenetics & Genomics, ISSN 1744-6872, E-ISSN 1744-6880, Vol. 23, nr 9, s. 463-469Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background Polymorphisms in ABCB1 have the ability to affect both the function and the expression of the transporter protein P-glycoprotein and may lead to an altered response for many drugs including some antidepressants and antipsychotics.Objective The aim of this study was to examine the impact of the ABCB1 polymorphisms 1199Gandgt;A, 1236Candgt;T, 2677Gandgt;T/A, and 3435Candgt;T in deaths by suicide.Patients and methods A total of 998 consecutive Swedish forensic autopsies performed in 2008 in individuals 18 years of age or older, where femoral blood was available and a toxicological screening had been performed, were investigated. Genotypes were assessed with pyrosequencing and information on the cause and manner of each death was obtained from the forensic pathology and toxicology databases.Results There was a significantly higher frequency of the T allele at positions 1236, 2677, and 3435 among the suicide cases compared with the nonsuicide cases.Conclusion Our result from forensic cases suggests that ABCB1 polymorphisms are associated with an increased risk for completed suicides. The biological mechanisms involved and the clinical implications for these findings are largely unknown and need to be examined further.

sted, utgiver, år, opplag, sider
Lippincott, Williams and Wilkins , 2013. Vol. 23, nr 9, s. 463-469
Emneord [en]
ABCB1, autopsy, forensic material, genotype, postmortem, sex, suicide
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Identifikatorer
URN: urn:nbn:se:liu:diva-97235DOI: 10.1097/FPC.0b013e328363a9bfISI: 000323220200002OAI: oai:DiVA.org:liu-97235DiVA, id: diva2:646170
Merknad

Funding Agencies|National Board of Forensic Medicine in Sweden||Swedish Research Council||Swedish Cancer Society||

Tilgjengelig fra: 2013-09-06 Laget: 2013-09-05 Sist oppdatert: 2017-12-06

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Boiso, SamuelZackrisson, Anna LenaJakobsen Falk, IngridKarlsson, LouiseCarlsson, BjörnKugelberg, FredrikAhlner, JohanHägg, StaffanGreen, Henrik

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Boiso, SamuelZackrisson, Anna LenaJakobsen Falk, IngridKarlsson, LouiseCarlsson, BjörnKugelberg, FredrikAhlner, JohanHägg, StaffanGreen, Henrik
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