liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Induction of ATP-binding cassette A1 by all-trans retinoic acid: possible role of liver X receptor-alpha
University of Örebro, Sweden.
University of Örebro, Sweden.
University of Örebro, Sweden.
2003 (engelsk)Inngår i: International Journal of Molecular Medicine, ISSN 1107-3756, E-ISSN 1791-244X, Vol. 11, nr 4, s. 419-423Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

ATP binding cassette A1 (ABCA1) is involved in the lipid metabolism of macrophages and has been suggested to play an important role in the development of foam cells and in the pathogenesis of atherosclerosis. We have investigated the effects of all-trans retinoic acid (atRA) on the mRNA and protein levels of ABCA1 in THP-1 cells. Our results show that both mRNA and protein levels of ABCA1 were significantly increased upon treatment with atRA. Since ABCA1 is highly regulated by liver X receptor (LXR) we also analysed the mRNA and protein expressions of LXR-alpha and LXR-6 in the THP-1 cells after treatment with atRA. Also the levels of LXR-alpha were increased by atRA. In conclusion, our results show that LXR-alpha and ABCA1 are simultaneously induced by atRA. The results also imply that the induction of ABCA1 by atRA may in part depend on the induction of LXR.

sted, utgiver, år, opplag, sider
Spandidos Publications , 2003. Vol. 11, nr 4, s. 419-423
Emneord [en]
human ABCA1; human LXR; atRA; RAR; atherosclerosis
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-100369ISI: 000181565400002PubMedID: 12632092OAI: oai:DiVA.org:liu-100369DiVA, id: diva2:661587
Tilgjengelig fra: 2013-11-04 Laget: 2013-11-04 Sist oppdatert: 2017-12-06bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

PubMed

Personposter BETA

Wågsäter, Dick

Søk i DiVA

Av forfatter/redaktør
Wågsäter, Dick
I samme tidsskrift
International Journal of Molecular Medicine

Søk utenfor DiVA

GoogleGoogle Scholar

pubmed
urn-nbn

Altmetric

pubmed
urn-nbn
Totalt: 49 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf