liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Essential Functions for ID Proteins at Multiple Checkpoints in Invariant NKT Cell Development
University of Chicago, IL 60637 USA University of Chicago, IL 60637 USA .
University of Chicago, IL 60637 USA .
Columbia University, NY 10032 USA Columbia University, NY 10032 USA Columbia University, NY 10032 USA .
Columbia University, NY 10032 USA Columbia University, NY 10032 USA Columbia University, NY 10032 USA .
Vise andre og tillknytning
2013 (engelsk)Inngår i: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 191, nr 12, s. 5973-5983Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Invariant NKT (iNKT) cells display characteristics of both adaptive and innate lymphoid cells (ILCs). Like other ILCs, iNKT cells constitutively express ID proteins, which antagonize the E protein transcription factors that are essential for adaptive lymphocyte development. However, unlike ILCs, ID2 is not essential for thymic iNKT cell development. In this study, we demonstrated that ID2 and ID3 redundantly promoted iNKT cell lineage specification involving the induction of the signature transcription factor PLZF and that ID3 was critical for development of TBET-dependent NKT1 cells. In contrast, both ID2 and ID3 limited iNKT cell numbers by enforcing the postselection checkpoint in conventional thymocytes. Therefore, iNKT cells show both adaptive and innate-like requirements for ID proteins at distinct checkpoints during iNKT cell development.

sted, utgiver, år, opplag, sider
American Association of Immunologists , 2013. Vol. 191, nr 12, s. 5973-5983
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-103291DOI: 10.4049/jimmunol.1301521ISI: 000328483900024OAI: oai:DiVA.org:liu-103291DiVA, id: diva2:688495
Tilgjengelig fra: 2014-01-17 Laget: 2014-01-16 Sist oppdatert: 2017-12-06

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekst

Personposter BETA

Sigvardsson, Mikael

Søk i DiVA

Av forfatter/redaktør
Sigvardsson, Mikael
Av organisasjonen
I samme tidsskrift
Journal of Immunology

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 40 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf