liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Olfactory Sensitivity and Odor Structure–Activity Relationships for Aliphatic Ketones in CD-1 Mice
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biologi. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0001-5583-2697
2014 (engelsk)Inngår i: Chemical Senses, ISSN 0379-864X, E-ISSN 1464-3553, Vol. 39, nr 5, 415-424 s.Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic 2-ketones(2-butanone to 2-nonanone) and several of their isomeric forms was investigated. With all 11 odorants, the animalssignificantly discriminated concentrations as low as 0.01 ppm (parts per million) from the solvent, and with two odorants(2-octanone and 5-nonanone), the best-scoring animals even detected concentrations as low as 3 ppt (parts per trillion).Analysis of odor structure–activity relationships showed that the correlation between olfactory detection thresholds of themice for the 2-ketones and carbon chain length can best be described as a U-shaped function with the lowest thresholdvalues at 2-octanone. Similarly, the correlation between olfactory sensitivity and carbon chain length of symmetricalketones (3-pentanone to 6-undecanone) can best be described as a U-shaped function. In contrast, no significantcorrelation was found between olfactory detection thresholds of the mice and position of the functional carbonyl groupattached to a C7 backbone. A comparison between the olfactory detection thresholds obtained here with those obtainedin earlier studies suggests that mice are significantly more sensitive for 2-ketones than for n-carboxylic acids of the samecarbon chain length. Across-species comparisons suggest that mice are significantly more sensitive for aliphatic ketonesthan squirrel monkeys and pigtail macaques, whereas the ranges of human olfactory detection threshold values overlapwith those of the mice with seven of the 11 ketones tested. Further comparisons suggest that odor structure–activityrelationships are both substance class and species specific.

sted, utgiver, år, opplag, sider
Oxford University Press, 2014. Vol. 39, nr 5, 415-424 s.
Emneord [en]
aliphatic ketones, CD-1 mice, odor structure-activity relationships, olfactory detection thresholds
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-106722DOI: 10.1093/chemse/bju011ISI: 000336984400004OAI: oai:DiVA.org:liu-106722DiVA: diva2:718144
Tilgjengelig fra: 2014-05-20 Laget: 2014-05-20 Sist oppdatert: 2017-12-05bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler

Andre lenker

Forlagets fulltekst

Personposter BETA

Laska, Matthias

Søk i DiVA

Av forfatter/redaktør
Laska, Matthias
Av organisasjonen
I samme tidsskrift
Chemical Senses

Søk utenfor DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric

doi
urn-nbn
Totalt: 171 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf