liu.seSearch for publications in DiVA
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Severe Eczema in Infancy Can Predict Asthma Development. A Prospective Study to the Age of 10 Years
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
Pediatric Clinic, Täby, Stockholm, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
Pediatric Clinic, County Hospital Ryhov, Jönköping, Sweden.
Vise andre og tillknytning
2014 (engelsk)Inngår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, nr 6, s. e99609-Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background: Children with atopic eczema in infancy often develop allergic rhinoconjunctivitis and asthma, but the term "atopic march has been questioned as the relations between atopic disorders seem more complicated than one condition progressing into another. Objective: In this prospective multicenter study we followed children with eczema from infancy to the age of 10 years focusing on sensitization to allergens, severity of eczema and development of allergic airway symptoms at 4.5 and 10 years of age. Methods: On inclusion, 123 children were examined. Hanifin-Rajka criteria and SCORAD index were used to describe the eczema. Episodes of wheezing were registered, skin prick tests and IgE tests were conducted and questionnaires were filled out. Procedures were repeated at 4.5 and 10 years of age with additional examinations for ARC and asthma. Results: 94 out of 123 completed the entire study. High SCORAD points on inclusion were correlated with the risk of developing ARC, (B = 9.86, P = 0.01) and asthma, (B = 10.17, P = 0.01). For infants with eczema and wheezing at the first visit, the OR for developing asthma was 4.05(P = 0.01). ARC at 4.5 years of age resulted in an OR of 11.28(P = 0.00) for asthma development at 10 years. Conclusion: This study indicates that infant eczema with high SCORAD points is associated with an increased risk of asthma at 10 years of age. Children with eczema and wheezing episodes during infancy are more likely to develop asthma than are infants with eczema alone. Eczema in infancy combined with early onset of ARC seems to indicate a more severe allergic disease, which often leads to asthma development. The progression from eczema in infancy to ARC at an early age and asthma later in childhood shown in this study supports the relevance of the term "atopic march, at least in more severe allergic disease.

sted, utgiver, år, opplag, sider
Public Library of Science , 2014. Vol. 9, nr 6, s. e99609-
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-110983DOI: 10.1371/journal.pone.0099609ISI: 000340947700119PubMedID: 24914552OAI: oai:DiVA.org:liu-110983DiVA, id: diva2:751621
Merknad

Funding Agencies|Health Research Council in the South-East of Sweden (FORSS); Swedish Asthma and Allergy Associations Research Foundation; Lions Club in the South-East of Sweden; GlaxoSmithKline; Konsul Th C Berghs Foundation for Scientific Research

Tilgjengelig fra: 2014-10-01 Laget: 2014-10-01 Sist oppdatert: 2017-12-05

Open Access i DiVA

fulltext(295 kB)130 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 295 kBChecksum SHA-512
b1f66f811879bcb3e2b27a30943cfbe5ec003428ff631e2607962c9ca3b1f9586686adb22888284318fd3b5d286ad10192ab22f3a2445498ef17c9c4271c6097
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Ekbäck, MarieDevenney, IreneFälth-Magnusson, Karin

Søk i DiVA

Av forfatter/redaktør
Ekbäck, MarieDevenney, IreneFälth-Magnusson, Karin
Av organisasjonen
I samme tidsskrift
PLoS ONE

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 130 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 232 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf