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Glucose Homeostasis Variables in Pregnancy versus Maternal and Infant Body Composition
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.ORCID-id: 0000-0003-2482-7048
Karolinska Institute, Sweden.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Medicinska fakulteten.
2015 (engelsk)Inngår i: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 7, nr 7, s. 5615-5627Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Intrauterine factors influence infant size and body composition but the mechanisms involved are to a large extent unknown. We studied relationships between the body composition of pregnant women and variables related to their glucose homeostasis, i.e., glucose, HOMA-IR (homeostasis model assessment-insulin resistance), hemoglobin A(1c) and IGFBP-1 (insulin-like growth factor binding protein-1), and related these variables to the body composition of their infants. Body composition of 209 women in gestational week 32 and of their healthy, singleton and full-term one-week-old infants was measured using air displacement plethysmography. Glucose homeostasis variables were assessed in gestational week 32. HOMA-IR was positively related to fat mass index and fat mass (r(2) = 0.32, p less than 0.001) of the women. Maternal glucose and HOMA-IR values were positively (p 0.006) associated, while IGFBP-1was negatively (p = 0.001) associated, with infant fat mass. HOMA-IR was positively associated with fat mass of daughters (p less than 0.001), but not of sons (p = 0.65) (Sex-interaction: p = 0.042). In conclusion, glucose homeostasis variables of pregnant women are related to their own body composition and to that of their infants. The results suggest that a previously identified relationship between fat mass of mothers and daughters is mediated by maternal insulin resistance.

sted, utgiver, år, opplag, sider
MDPI , 2015. Vol. 7, nr 7, s. 5615-5627
Emneord [en]
body composition; infant; insulin resistance; pregnancy; sex difference
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-121143DOI: 10.3390/nu7075243ISI: 000359349800033PubMedID: 26184296OAI: oai:DiVA.org:liu-121143DiVA, id: diva2:852262
Merknad

Funding Agencies|Swedish Research Council [15402]; Swedish Research Council Formas [2008-1332, 2006-614]; Medical Faculty, Linkoping University; County Council of Ostergotland

Tilgjengelig fra: 2015-09-08 Laget: 2015-09-08 Sist oppdatert: 2019-06-28

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