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High-Resolution Laser Doppler Measurements of Microcirculation in the Deep Brain Structures: A Method for Potential Vessel Tracking.
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten. Linköpings universitet, Centrum för medicinsk bildvetenskap och visualisering, CMIV. (MINT)ORCID-id: 0000-0002-0012-7867
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten. University of Applied Sciences and Arts Northwestern Switzerland, Muttenz , Switzerland. (MINT)
Linköpings universitet, Institutionen för medicinsk teknik, Biomedicinsk instrumentteknik. Linköpings universitet, Tekniska fakulteten. (MINT)
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för neuro- och inflammationsvetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Sinnescentrum, Neurokirurgiska kliniken US.
2016 (engelsk)Inngår i: Stereotactic and Functional Neurosurgery, ISSN 1011-6125, E-ISSN 1423-0372, Vol. 94, nr 1, s. 1-9Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

BACKGROUND: Laser Doppler flowmetry (LDF) can be used to measure cerebral microcirculation in relation to stereotactic deep brain stimulation (DBS) implantations.

OBJECTIVE: To investigate the microcirculation and total light intensity (TLI) corresponding to tissue grayness in DBS target regions with high-resolution LDF recordings, and to define a resolution which enables detection of small vessels.

METHODS: Stereotactic LDF measurements were made prior to DBS implantation with 0.5-mm steps in the vicinity to 4 deep brain targets (STN, GPi, Vim, Zi) along 20 trajectories. The Mann-Whitney U test was used to compare the microcirculation and TLI between targets, and the measurement resolution (0.5 vs. 1 mm). The numbers of high blood flow spots along the trajectories were calculated.

RESULTS: There was a significant difference (p < 0.05) in microcirculation between the targets. High blood flow spots were present at 15 out of 510 positions, 7 along Vim and GPi trajectories, respectively. There was no statistical difference between resolutions even though both local blood flow and TLI peaks could appear at 0.5-mm steps.

CONCLUSIONS: LDF can be used for online tracking of critical regions presenting blood flow and TLI peaks, possibly relating to vessel structures and thin laminas along stereotactic trajectories.

sted, utgiver, år, opplag, sider
S. Karger, 2016. Vol. 94, nr 1, s. 1-9
Emneord [en]
Deep brain stimulation · Laser Doppler flowmetry ·Stereotactic neurosurgery · Microcirculation · Navigation
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Identifikatorer
URN: urn:nbn:se:liu:diva-124691DOI: 10.1159/000442894ISI: 000373869900001PubMedID: 26795207OAI: oai:DiVA.org:liu-124691DiVA, id: diva2:902056
Merknad

Funding agencies:  Swedish Research Council [621-2013-6078]; Parkinson Foundation at Linkoping University; Swiss National Science Foundation [205321-135285]

Tilgjengelig fra: 2016-02-10 Laget: 2016-02-10 Sist oppdatert: 2017-11-30bibliografisk kontrollert

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Wårdell, KarinHemm-Ode, SimoneRejmstad, PeterZsigmond, Peter

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