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Regulation of CD8+T-cell cytotoxicity in HIV-1 infection
University of Malaya, Malaysia.
University of Penn, PA 19104 USA.
Karolinska Institute, Sweden.
University of Malaya, Malaysia.
Vise andre og tillknytning
2015 (engelsk)Inngår i: Cellular Immunology, ISSN 0008-8749, E-ISSN 1090-2163, Vol. 298, nr 1-2, s. 126-133Artikkel, forskningsoversikt (Fagfellevurdert) Published
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Abstract [en]

Understanding the mechanisms involved in cellular immune responses against control of human immunodeficiency virus (HIV) infection is key to development of effective immunotherapeutic strategies against viral proliferation. Clear insights into the regulation of cytotoxic CD8+ T cells is crucial to development of effective immunotherapeutic strategies due to their unique ability to eliminate virus-infected cells during the course of infection. Here, we reviewed the roles of transcription factors, co-inhibitory molecules and regulatory cytokines following HIV infection and their potential significance in regulating the cytotoxic potentials of CD8+ T cells. (C) 2015 Elsevier Inc. All rights reserved.

sted, utgiver, år, opplag, sider
ACADEMIC PRESS INC ELSEVIER SCIENCE , 2015. Vol. 298, nr 1-2, s. 126-133
Emneord [en]
HIV; CD8+T cells; Perforin; Cytotoxicity; Transcription factors; Cytokines
HSV kategori
Identifikatorer
URN: urn:nbn:se:liu:diva-125694DOI: 10.1016/j.cellimm.2015.10.009ISI: 000369168400016PubMedID: 26520669OAI: oai:DiVA.org:liu-125694DiVA, id: diva2:908196
Tilgjengelig fra: 2016-03-01 Laget: 2016-02-29 Sist oppdatert: 2017-11-30

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