liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Emerging tick-borne pathogens in the Nordic countries: A clinical and laboratory follow-up study of high-risk tick-bitten individuals
Statens Serum Inst, Denmark; Rigshosp, Denmark.
Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för inflammation och infektion. Linköpings universitet, Medicinska fakulteten. Cty Hosp Ryhov, Sweden.
Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för inflammation och infektion. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Medicincentrum, Infektionskliniken i Östergötland.ORCID-id: 0000-0001-5622-866X
Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Avdelningen för inflammation och infektion. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Diagnostikcentrum, Klinisk mikrobiologi. Division of Clinical Microbiology, Laboratory Medicine, Jönköping Region Jönköping County, Sweden.ORCID-id: 0000-0002-9315-8901
Visa övriga samt affilieringar
2020 (Engelska)Ingår i: Ticks and Tick-borne Diseases, ISSN 1877-959X, E-ISSN 1877-9603, Vol. 11, nr 1, artikel-id UNSP 101303Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Despite the presence of several microorganisms, other than Borrelia burgdorferi sensu lato (Bbsl) and TBE virus, in Ixodes ricinus ticks from the Nordic countries, data is lacking on their pathogenic potential in humans. In this study, we wanted to investigate the aetiology and clinical manifestations of tick-transmitted infections in individuals seeking medical care following a tick-bite. The sampling frame was participants of a large-scale, prospective, multi-centre, follow-up study of tick-bitten volunteers recruited in Sweden, Finland and Norway in the years 2007-2015. Participants who sought medical care during the three-month follow-up period and from whom blood samples were collected during this healthcare visit (n=92) were tested, using PCR, for exposure to spotted fever group (SFG) Rickettsia spp., Anaplasma phagocytophilum and Babesia spp. Moreover, 86 of these individuals had two serum samples, collected three months apart, tested serologically for six tick-borne microorganisms. The selected organisms-Bbsl, SFG rickettsiae, Anaplasma phagocytophilum, TBE virus, Babesia microti and Bartonella henselae-have all been detected in field-collected ticks from the Nordic countries. Medical records were reviewed and questionnaires were completed to determine clinical manifestations. We found Lyme borreliosis to be the most common tick-transmitted infection as seen in 46 (54%) of the 86 participants with available medical records. Among the 86 participants with paired sera, serological or molecular evidence of recent exposure to other microorganisms than Bbsl could be demonstrated in eight (9%). Five participants (6%) exhibited serological evidence of recent concomitant exposure to more than one tick-borne microorganism. Clinical presentations were mild with one exception (TBE). In conclusion, our data suggest a low risk of infection with tick-borne microorganisms, other than Bbsl, in immunocompetent tick-bitten persons from the examined regions, a low occurrence of co-infection and mostly mild or no overt clinical signs of infection in immunocompetent persons exposed to the studied agents.

Ort, förlag, år, upplaga, sidor
ELSEVIER GMBH , 2020. Vol. 11, nr 1, artikel-id UNSP 101303
Nyckelord [en]
Tick-transmitted infections; Vector-borne infections; Public health; Emerging infections; Tick-borne pathogens; Co-infections
Nationell ämneskategori
Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:liu:diva-162487DOI: 10.1016/j.ttbdis.2019.101303ISI: 000497952700007PubMedID: 31631052OAI: oai:DiVA.org:liu-162487DiVA, id: diva2:1379025
Anmärkning

Funding Agencies|EUEuropean Union (EU) [20200422]; Swedish Research Council Branch of MedicineSwedish Research Council [K2008-58X-14631-06-3]; Medical Research Council of Southeast Sweden; County Council of Ostergotland [LIO-56191]; Independent Research Fund Denmark [8020-00344B]; Wilhelm and Else Stockmann Foundation; Foundation for Aland Medical Research of the Aland Culture Foundation

Tillgänglig från: 2019-12-16 Skapad: 2019-12-16 Senast uppdaterad: 2021-12-29

Open Access i DiVA

fulltext(2745 kB)277 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 2745 kBChecksumma SHA-512
06c8d57daf14fd3ddec741e609cbf54f6dbd57d5dc554f7e659f28f81300e47efc45213b749444e1ba09f08ef8c78aec99e63e8e5afed33f5530a3c6ca80929c
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Person

Wilhelmsson, PeterSjöwall, JohannaHenningsson, Anna J.Forsberg, Pia

Sök vidare i DiVA

Av författaren/redaktören
Wilhelmsson, PeterSjöwall, JohannaHenningsson, Anna J.Forsberg, PiaLindgren, Per-Eric
Av organisationen
Avdelningen för inflammation och infektionMedicinska fakultetenInfektionskliniken i ÖstergötlandKlinisk mikrobiologi
I samma tidskrift
Ticks and Tick-borne Diseases
Infektionsmedicin

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 277 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 316 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf