liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies
Harvard TH Chan School Public Heatlh, MA USA; University of Maryland, MD 21201 USA.
Harvard TH Chan School Public Heatlh, MA USA; Harvard TH Chan School Public Heatlh, MA USA.
University of Minnesota, MN USA; University of Minnesota, MN USA.
Cancer Council Victoria, Australia; University of Melbourne, Australia.
Visa övriga samt affilieringar
2016 (Engelska)Ingår i: International Journal of Epidemiology, ISSN 0300-5771, E-ISSN 1464-3685, Vol. 45, nr 3, s. 916-928Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Breast cancer aetiology may differ by estrogen receptor (ER) status. Associations of alcohol and folate intakes with risk of breast cancer defined by ER status were examined in pooled analyses of the primary data from 20 cohorts. Methods: During a maximum of 6-18 years of follow-up of 1 089 273 women, 21 624 ER+ and 5113 ER- breast cancers were identified. Study-specific multivariable relative risks (RRs) were calculated using Cox proportional hazards regression models and then combined using a random-effects model. Results: Alcohol consumption was positively associated with risk of ER+ and ER- breast cancer. The pooled multivariable RRs (95% confidence intervals) comparing amp;gt;= 30 g/d with 0 g/day of alcohol consumption were 1.35 (1.23-1.48) for ER+ and 1.28 (1.10-1.49) for ER+ breast cancer (P-trend amp;lt;= 0.001; Pcommon-effects by ER status: 0.57). Associations were similar for alcohol intake from beer, wine and liquor. The associations with alcohol intake did not vary significantly by total (from foods and supplements) folate intake (P-interaction amp;gt;= 0.26). Dietary (from foods only) and total folate intakes were not associated with risk of overall, ER+ and ER- breast cancer; pooled multivariable RRs ranged from 0.98 to 1.02 comparing extreme quintiles. Following-up US studies through only the period before mandatory folic acid fortification did not change the results. The alcohol and folate associations did not vary by tumour subtypes defined by progesterone receptor status. Conclusions: Alcohol consumption was positively associated with risk of both ER+ and ER- breast cancer, even among women with high folate intake. Folate intake was not associated with breast cancer risk.

Ort, förlag, år, upplaga, sidor
OXFORD UNIV PRESS , 2016. Vol. 45, nr 3, s. 916-928
Nyckelord [en]
Alcohol; folate; breast cancer; estrogen receptor; progesterone receptor; pooled analyses; epidemiology; cohort study
Nationell ämneskategori
Cancer och onkologi
Identifikatorer
URN: urn:nbn:se:liu:diva-132357DOI: 10.1093/ije/dyv156ISI: 000384653200044PubMedID: 26320033OAI: oai:DiVA.org:liu-132357DiVA, id: diva2:1046183
Anmärkning

Funding Agencies|National Institute of Health [CA55075]; Breast Cancer Research Foundation

Tillgänglig från: 2016-11-12 Skapad: 2016-11-01 Senast uppdaterad: 2019-06-28

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Sök vidare i DiVA

Av författaren/redaktören
Löf, Marie
Av organisationen
Avdelningen för kliniska vetenskaperMedicinska fakulteten
I samma tidskrift
International Journal of Epidemiology
Cancer och onkologi

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 70 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf