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Expansion of spatial and host range of Puumala virus in Sweden: an increasing threat for humans?
Uppsala University, Sweden.
Uppsala University, Sweden.
Swedish University of Agriculture Science, Sweden.
Swedish University of Agriculture Science, Sweden; Stockholm University, Sweden.
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2017 (Engelska)Ingår i: Epidemiology and Infection, ISSN 0950-2688, E-ISSN 1469-4409, Vol. 145, nr 8, s. 1642-1648Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Hantaviruses are globally distributed and cause severe human disease. Puumala hantavirus (PUUV) is the most common species in Northern Europe, and the only hantavirus confirmed to circulate in Sweden, restricted to the northern regions of the country. In this study, we aimed to further add to the natural ecology of PUUV in Sweden by investigating prevalence, and spatial and host species infection patterns. Specifically, we wanted to ascertain whether PUUV was present in the natural reservoir, the bank vole (Myodes glareolus) further south than Dalalven river, in south-central Sweden, and whether PUUV can be detected in other rodent species in addition to the natural reservoir. In total, 559 animals were collected at Grimso (59 degrees 43 N; 15 degrees 28 E), Sala (59 degrees 55 N; 16 degrees 36 E) and Bogesund (59 degrees 24 N; 18 degrees 14 E) in south-central Sweden between May 2013 and November 2014. PUUV ELISA-reactive antibodies were found both in 2013 (22/295) and in 2014 (18/264), and nine samples were confirmed as PUUV-specific by focus reduction neutralization test. Most of the PUUV-specific samples were from the natural host, the bank vole, but also from other rodent hosts, indicating viral spill-over. Finally, we showed that PUUV is present in more highly populated central Sweden.

Ort, förlag, år, upplaga, sidor
CAMBRIDGE UNIV PRESS , 2017. Vol. 145, nr 8, s. 1642-1648
Nyckelord [en]
Bank vole; Bunyaviridae; disease emergence; hantavirus; Myodes glareolus; Puumala virus; Sweden; zoonosis
Nationell ämneskategori
Infektionsmedicin
Identifikatorer
URN: urn:nbn:se:liu:diva-138899DOI: 10.1017/S0950268817000346ISI: 000402918700015PubMedID: 28249631OAI: oai:DiVA.org:liu-138899DiVA, id: diva2:1115912
Anmärkning

Funding Agencies|EU [FP7-261504 EDENext]; Swedish Environmental Protection Agency project; Swedish Hunters Organization; foundation Marie-Claire Cronstedt stiftelse; EU Interreg - ScandTick Innovation

Tillgänglig från: 2017-06-27 Skapad: 2017-06-27 Senast uppdaterad: 2017-06-27

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Lindgren, Per-Eric
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Avdelningen för mikrobiologi och molekylär medicinMedicinska fakulteten
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Epidemiology and Infection
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