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Specification of Neuropeptide Cell Identity by the Integration of Retrograde BMP Signaling and a Combinatorial Transcription Factor Code
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115 USA.ORCID-id: 0000-0001-5095-541X
2003 (Engelska)Ingår i: Cell, ISSN 0092-8674, E-ISSN 1097-4172, Vol. 113, nr 1, s. 73-86Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Individual neurons express only one or a few of the many identified neurotransmitters and neuropeptides, but the molecular mechanisms controlling their selection are poorly understood. In the Drosophila ventral nerve cord, the six Tv neurons express the neuropeptide gene FMRFamide. Each Tv neuron resides within a neuronal cell group specified by the LIM-homeodomain gene apterous. We find that the zinc-finger gene squeeze acts in Tv cells to promote their unique axon pathfinding to a peripheral target. There, the BMP ligand Glass bottom boat activates the Wishful thinking receptor, initiating a retrograde BMP signal in the Tv neuron. This signal acts together with apterous and squeeze to activate FMRFamide expression. Reconstituting this "code," by combined BMP activation and apterous/squeeze misexpression, triggers ectopic FMRFamide expression in peptidergic neurons. Thus, an intrinsic transcription factor code integrates with an extrinsic retrograde signal to select a specific neuropeptide identity within peptidergic cells.

Ort, förlag, år, upplaga, sidor
Cambridge, United States: Cell Press , 2003. Vol. 113, nr 1, s. 73-86
Nationell ämneskategori
Utvecklingsbiologi
Identifikatorer
URN: urn:nbn:se:liu:diva-142305DOI: 10.1016/S0092-8674(03)00204-6ISI: 000182282900008PubMedID: 12679036Scopus ID: 2-s2.0-0037418870OAI: oai:DiVA.org:liu-142305DiVA, id: diva2:1152567
Tillgänglig från: 2017-10-25 Skapad: 2017-10-25 Senast uppdaterad: 2018-11-27Bibliografiskt granskad

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