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A LIM-homeodomain combinatorial code for motor-neuron pathway selection.
Molecular Neurobiology Laboratory, The Salk Institute, PO Box 85800, San Diego, California 92186, USA.ORCID-id: 0000-0001-5095-541X
Center for Neurobiology and Behavior, Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York 10032, USA.
Center for Neurobiology and Behavior, Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, 701 West 168th Street, New York, New York 10032, USA.
Molecular Neurobiology Laboratory, The Salk Institute, PO Box 85800, San Diego, California 92186, USA.
1999 (Engelska)Ingår i: Nature, ISSN 0028-0836, E-ISSN 1476-4687, Vol. 397, nr 6714, s. 76-80Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Different classes of vertebrate motor neuron that innervate distinct muscle targets express unique combinations of LIM-homeodomain transcription factors, suggesting that a combinatorial code of LIM-homeodomain proteins may underlie the control of motor-neuron pathway selection. Studies of LIM-homeodomain genes in mouse, Drosophila melanogaster and Caenorhabditis elegans have revealed functions of these genes in neuronal survival, axon guidance, neurotransmitter expression and neuronal function, but, to our knowledge, none of these studies have addressed the issue of a functional code. Here we study two members of this gene family in Drosophila, namely lim3, the homologue of the vertebrate Lhx3 and Lhx4 genes, and islet, the homologue of the vertebrate Isl1 and Is12 genes. We show that Drosophila lim3 is expressed by a specific subset of islet-expressing motor neurons and that mutating or misexpressing lim3 switches motor-neuron projections predictably. Our results provide evidence that lim3 and islet constitute a combinatorial code that generates distinct motor-neuron identities.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group, 1999. Vol. 397, nr 6714, s. 76-80
Nationell ämneskategori
Neurovetenskaper
Identifikatorer
URN: urn:nbn:se:liu:diva-142307DOI: 10.1038/16275ISI: 000077959400051PubMedID: 9892357Scopus ID: 2-s2.0-0033531216OAI: oai:DiVA.org:liu-142307DiVA, id: diva2:1152571
Tillgänglig från: 2017-10-25 Skapad: 2017-10-25 Senast uppdaterad: 2018-11-27Bibliografiskt granskad

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