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Redox-active conducting polymers modulate Salmonella biofilm formation by controlling availability of electron acceptors (vol 3, article number 19, 2017)
Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden.
Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden.
Department of Neuroscience, Swedish Medical Nanoscience Center, Karolinska Institutet, Sweden.
Linköpings universitet, Institutionen för teknik och naturvetenskap, Fysik och elektroteknik. Linköpings universitet, Tekniska fakulteten.
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2018 (Engelska)Ingår i: npj Biofilms and Microbiomes, ISSN 2055-5008, Vol. 3, artikel-id 19Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Biofouling is a major problem caused by bacteria colonizing abiotic surfaces, such as medical devices. Biofilms are formed as the bacterial metabolism adapts to an attached growth state. We studied whether bacterial metabolism, hence biofilm formation, can be modulated in electrochemically active surfaces using the conducting conjugated polymer poly(3,4-ethylenedioxythiophene) (PEDOT). We fabricated composites of PEDOT doped with either heparin, dodecyl benzene sulfonate or chloride, and identified the fabrication parameters so that the electrochemical redox state is the main distinct factor influencing biofilm growth. PEDOT surfaces fitted into a custom-designed culturing device allowed for redox switching in Salmonella cultures, leading to oxidized or reduced electrodes. Similarly large biofilm growth was found on the oxidized anodes and on conventional polyester. In contrast, biofilm was significantly decreased (52-58%) on the reduced cathodes. Quantification of electrochromism in unswitched conducting polymer surfaces revealed a bacteria-driven electrochemical reduction of PEDOT. As a result, unswitched PEDOT acquired an analogous electrochemical state to the externally reduced cathode, explaining the similarly decreased biofilm growth on reduced cathodes and unswitched surfaces. Collectively, our findings reveal two opposing effects affecting biofilm formation. While the oxidized PEDOT anode constitutes a renewable electron sink that promotes biofilm growth, reduction of PEDOT by a power source or by bacteria largely suppresses biofilm formation. Modulating bacterial metabolism using the redox state of electroactive surfaces constitutes an unexplored method with applications spanning from antifouling coatings and microbial fuel cells to the study of the role of bacterial respiration during infection.

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2018. Vol. 3, artikel-id 19
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URN: urn:nbn:se:liu:diva-151745DOI: 10.1038/s41522-017-0027-0ISI: 000412923600001PubMedID: 28883986OAI: oai:DiVA.org:liu-151745DiVA, id: diva2:1253165
Anmärkning

An author correction to this article was published with the DOI: 10.1038/s41522-018-0061-6 and is registered in DiVA: http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-151743

Tillgänglig från: 2018-10-04 Skapad: 2018-10-04 Senast uppdaterad: 2018-12-20

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Persson, Kristin M.Jager, EdwinBerggren, Magnus

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