The vertebrate zygote results from the merging of two highly specialized gamete cells, namely the oocyte and the spermatozoon, and has the outstanding potential of creating all cells in the future developing embryo. For this to occur, however, the genome of the gametes is mostly striped of “epigenetic marks,” or proteins and methyl groups attached to the DNA. Epigenetic marks in the genome constitute the so-called epigenome and have the potential for long term regulation of gene expression. Environmental insults during the highly susceptible and delicate period of germ cell development could, by altering the epigenome of spermatozoa, affect the phenotype of future generations (transgenerational epigenetic inheritance). A brief review of how epigenetics can act transgenerationally through the male germline is hereby presented.