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Bivalirudin versus heparin monotherapy in non-ST-segment elevation myocardial infarction.
Department of Cardiology, Lund University, Sweden.
Department of Cardiology, Lund University, Sweden.
Department of Cardiology, Sahlgrenska University Hospital, Sweden.
Department of Cardiology, Örebro University, Sweden.
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2018 (Engelska)Ingår i: European Heart Journal. Acute Cardiovascular Care, ISSN 2048-8734Artikel i tidskrift (Refereegranskat) Epub ahead of print
Abstract [en]

Background: The optimal anti-coagulation strategy for patients with non-ST-elevation myocardial infarction treated with percutaneous coronary intervention is unclear in contemporary clinical practice of radial access and potent P2Y12-inhibitors. The aim of this study was to investigate whether bivalirudin was superior to heparin monotherapy in patients with non-ST-elevation myocardial infarction without routine glycoprotein IIb/IIIa inhibitor use.less thanbr /greater thanMethods: In a large pre-specified subgroup of the multicentre, prospective, randomised, registry-based, open-label clinical VALIDATE-SWEDEHEART trial we randomised patients with non-ST-elevation myocardial infarction undergoing percutaneous coronary intervention, treated with ticagrelor or prasugrel, to bivalirudin or heparin monotherapy with no planned use of glycoprotein IIb/IIIa inhibitors during percutaneous coronary intervention. The primary endpoint was the rate of a composite of all-cause death, myocardial infarction or major bleeding within 180 days.less thanbr /greater thanResults: A total of 3001 patients with non-ST-elevation myocardial infarction, were enrolled. The primary endpoint occurred in 12.1% (182 of 1503) and 12.5% (187 of 1498) of patients in the bivalirudin and heparin groups, respectively (hazard ratio of bivalirudin compared to heparin treatment 0.96, 95% confidence interval 0.78-1.18, p=0.69). The results were consistent in all major subgroups. All-cause death occurred in 2.0% versus 1.7% (hazard ratio 1.15, 0.68-1.94, p=0.61), myocardial infarction in 2.3% versus 2.5% (hazard ratio 0.91, 0.58-1.45, p=0.70), major bleeding in 8.9% versus 9.1% (hazard ratio 0.97, 0.77-1.24, p=0.82) and definite stent thrombosis in 0.3% versus 0.2% (hazard ratio 1.33, 0.30-5.93, p=0.82).less thanbr /greater thanConclusion: Bivalirudin as compared to heparin during percutaneous coronary intervention for non-ST-elevation myocardial infarction did not reduce the composite of all-cause death, myocardial infarction or major bleeding in non-ST-elevation myocardial infarction patients receiving current recommended treatments with modern P2Y12-inhibitors and predominantly radial access.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2018.
Nyckelord [en]
Bivalirudin; heparin; non-ST-elevation myocardial infarction
Nationell ämneskategori
Kardiologi
Identifikatorer
URN: urn:nbn:se:liu:diva-155804DOI: 10.1177/2048872618805663PubMedID: 30281320OAI: oai:DiVA.org:liu-155804DiVA, id: diva2:1299630
Forskningsfinansiär
Hjärt-LungfondenVetenskapsrådetStiftelsen för strategisk forskning (SSF)Tillgänglig från: 2019-03-28 Skapad: 2019-03-28 Senast uppdaterad: 2019-03-28

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Venetsanos, Dimitrios

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