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Tumor-derived exosomes: Implication in angiogenesis and antiangiogenesis cancer therapy
Tabriz Univ Med Sci, Iran.
Kermanshah Univ Med Sci, Iran.
Kermanshah Univ Med Sci, Iran.
Tabriz Univ Med Sci, Iran.
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2019 (Engelska)Ingår i: Journal of Cellular Physiology, ISSN 0021-9541, E-ISSN 1097-4652, Vol. 234, nr 10, s. 16885-16903Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

Tumor cells utilize different strategies to communicate with neighboring tissues for facilitating tumor progression and invasion, one of these strategies has been shown to be the release of exosomes. Exosomes are small nanovesicles secreted by all kind of cells in the body, especially cancer cells, and mediate cell to cell communications. Exosomes play an important role in cancer invasiveness by harboring various cargoes that could accelerate angiogenesis. Here first, we will present an overview of exosomes, their biology, and their function in the body. Then, we will focus on exosomes derived from tumor cells as tumor angiogenesis mediators with a particular emphasis on the underlying mechanisms in various cancer origins. Also, exosomes derived from stem cells and tumor-associated macrophages will be discussed in this regard. Finally, we will discuss the novel therapeutic strategies of exosomes as drug delivery vehicles against angiogenesis.

Ort, förlag, år, upplaga, sidor
WILEY , 2019. Vol. 234, nr 10, s. 16885-16903
Nyckelord [en]
angiogenesis; cancer therapy; exosomes; extracellular vesicles; tumor
Nationell ämneskategori
Cell- och molekylärbiologi
Identifikatorer
URN: urn:nbn:se:liu:diva-159119DOI: 10.1002/jcp.28374ISI: 000474688200017PubMedID: 30793767OAI: oai:DiVA.org:liu-159119DiVA, id: diva2:1339684
Tillgänglig från: 2019-07-30 Skapad: 2019-07-30 Senast uppdaterad: 2019-07-30

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Kharaziha, Pedram
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Avdelningen för cellbiologiMedicinska fakultetenKlinisk genetik
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Journal of Cellular Physiology
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