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The future of translational research on alcohol use disorder
Univ Calif Los Angeles, CA 90095 USA.
Univ Calif Los Angeles, CA 90095 USA.
NIDA, MD USA; Brown Univ, RI 02912 USA.
NIAAA, MD USA.
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2021 (Engelska)Ingår i: Addiction Biology, ISSN 1355-6215, E-ISSN 1369-1600, Vol. 26, nr 2, artikel-id e12903Artikel, forskningsöversikt (Refereegranskat) Published
Abstract [en]

In March 2019, a scientific meeting was held at the University of California, Los Angeles (UCLA) Luskin Center to discuss approaches to expedite the translation of neurobiological insights to advances in the treatment of alcohol use disorder (AUD). A guiding theme that emerged was that while translational research in AUD is clearly a challenge, it is also a field ripe with opportunities. Herein, we seek to summarize and disseminate the recommendations for the future of translational AUD research using four sections. First, we briefly review the current landscape of AUD treatment including the available evidence-based treatments and their uptake in clinical settings. Second, we discuss AUD treatment development efforts from a translational science viewpoint. We review current hurdles to treatment development as well as opportunities for mechanism-informed treatment. Third, we consider models of translational science and public health impact. Together, these critical insights serve as the bases for a series of recommendations and future directions. Towards the goal of improving clinical care and population health for AUD, scientists are tasked with bolstering the clinical applicability of their research findings so as to expedite the translation of knowledge into patient care.

Ort, förlag, år, upplaga, sidor
WILEY , 2021. Vol. 26, nr 2, artikel-id e12903
Nyckelord [en]
AUD; medications; research; translational; treatment; treatment gap
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URN: urn:nbn:se:liu:diva-165400DOI: 10.1111/adb.12903ISI: 000525881600001PubMedID: 32286721OAI: oai:DiVA.org:liu-165400DiVA, id: diva2:1427748
Anmärkning

Funding Agencies|National Institute on Alcohol Abuse and Alcoholism (NIAAA)United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) [K24AA025704]; UCLA Meyer and Renee Luskin Lecture for Thought Leadership in the College of Letters and Sciences

Tillgänglig från: 2020-04-30 Skapad: 2020-04-30 Senast uppdaterad: 2021-04-20

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