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Photopheresis at onset of type 1 diabetes: A randomised, double blind, placebo controlled trial
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Pediatrik. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Pediatrik. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn.
Linköpings universitet, Hälsouniversitetet. Linköpings universitet, Institutionen för molekylär och klinisk medicin, Klinisk immunologi. Östergötlands Läns Landsting, Laboratoriemedicinskt centrum, Klinisk immunologi och transfusionsmedicin.ORCID-id: 0000-0001-9456-2044
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2001 (Engelska)Ingår i: Archives of Disease in Childhood, ISSN 0003-9888, E-ISSN 1468-2044, Vol. 85, nr 2, s. 149-154Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background - In recent years photopheresis, an extracorporeal form of photochemotherapy using psoralen and ultraviolet A irradiation of leucocytes, has been claimed to be an effective form of immunomodulation. Aim - To evaluate its effect in type 1 diabetes we performed a double blind, controlled study using placebo tablets and sham pheresis in the control group. Methods - A total of 49 children, aged 10-18 years of age at diagnosis of type 1 diabetes were included, 40 fulfilled the study and were followed for three years (19 received active treatment with photopheresis and 21 placebo treatment). Results - The actively treated children secreted significantly more C peptide in urine during follow up than control children. C peptide values in serum showed corresponding differences between the two groups. The insulin dose/kg body weight needed to achieve satisfactory HbA1c values was always lower in the photopheresis group, there was no difference between the groups regarding HbAlc values during follow up. The treatment was well accepted except for nausea (n = 3) and urticaria (n = 1) in the actively treated group. There were no differences regarding weight or height, or episodes of infection between the two groups during follow up. Conclusion - Photopheresis does have an effect in addition to its possible placebo effect, shown as a weak but significant effect on the disease process at the onset of type 1 diabetes, an effect still noted after three years of follow up.

Ort, förlag, år, upplaga, sidor
2001. Vol. 85, nr 2, s. 149-154
Nationell ämneskategori
Medicin och hälsovetenskap
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URN: urn:nbn:se:liu:diva-25804DOI: 10.1136/adc.85.2.149Lokalt ID: 10241OAI: oai:DiVA.org:liu-25804DiVA, id: diva2:246352
Tillgänglig från: 2009-10-08 Skapad: 2009-10-08 Senast uppdaterad: 2020-01-16

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Ludvigsson, JohnnySamuelsson, UlfErnerudh, JanStenhammar, LarsBerlin, Gösta

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Ludvigsson, JohnnySamuelsson, UlfErnerudh, JanStenhammar, LarsBerlin, Gösta
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HälsouniversitetetPediatrikBarnKlinisk immunologiKlinisk immunologi och transfusionsmedicinTransfusionsmedicin
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