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Increase in interstitial interleukin-6 of human skeletal muscle with repetitive low-force exercise
Östergötlands Läns Landsting, Smärt- och yrkesmedicinskt centrum.
National Institute of Occupational Health, Copenhagen.
Bispebjerg Hospital.
National Institute of Occupational Health, Copenhagen.
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2005 (Engelska)Ingår i: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 98, nr 2, s. 477-481Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Interleukin (IL)-6, which is released from muscle tissue during intense exercise, possesses important metabolic and probably anti-inflammatory properties. To evaluate the IL-6 response to low-intensity exercise, we conducted two studies: 1) a control study with insertion of microdialysis catheters in muscle and determination of interstitial muscle IL-6 response over 2 h of rest and 2) an exercise study to investigate the IL-6 response to 20 min of repetitive low-force exercise. In both studies, a microdialysis catheter (cutoff: 3,000 kDa) was inserted into the upper trapezius muscle of six male subjects, and the catheters were perfused with Ringer-acetate at 5 mul/min. Venous plasma samples were taken in the exercise study. The insertion of microdialysis catheters into muscle resulted in an increase in IL-6 from 8 +/- 0 to 359 +/- 171 and 484 +/- 202 pg/ml after 65 and 110 min, respectively (P less than 0.001). Similarly, in the exercise study, IL-6 increased to 289 +/- 128 pg/ml after a 55-min rest (P less than 0.001). During the subsequent repetitive low-force exercise, muscle IL-6 further increased to 1,246 +/- 461 pg/ml and reached 2,132 +/- 477 pg/ml after a 30-min recovery ( all P less than 0.001). In contrast to this, plasma IL-6 did not significantly change in response to exercise. We conclude that upper extremity, low-intensity exercise results in a substantial increase in IL-6 in the interstitium of the stabilizing trapezius muscle, whereas no change is seen for plasma IL-6.

Ort, förlag, år, upplaga, sidor
2005. Vol. 98, nr 2, s. 477-481
Nyckelord [en]
metabolism; trauma; inflammation; cytokine; microdialysis
Nationell ämneskategori
Teknik och teknologier
Identifikatorer
URN: urn:nbn:se:liu:diva-53514DOI: 10.1152/japplphysiol.00130.2004OAI: oai:DiVA.org:liu-53514DiVA, id: diva2:289713
Tillgänglig från: 2010-01-25 Skapad: 2010-01-25 Senast uppdaterad: 2017-12-12

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