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Asymptomatic Norovirus Infections in Nicaraguan Children and its Association With Viral Properties and Histo-blood Group Antigens
University of Leon.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Medicinsk mikrobiologi. Linköpings universitet, Hälsouniversitetet.
University of Leon.
Karolinska Institute.
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2010 (Engelska)Ingår i: PEDIATRIC INFECTIOUS DISEASE JOURNAL, ISSN 0891-3668, Vol. 29, nr 10, s. 934-939Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: It has been previously reported that histo-blood group antigens (HBGAs) and particularly secretor status provides protection against symptomatic norovirus infection, but it remains unclear to what extent this includes asymptomatic infections in children. Methods: To explore whether HBGAs or certain viral genotypes are associated with asymptomatic norovirus infections in a pediatric population in Nicaragua, we investigated 163 children andlt;= 5 years of age, without a recent history of diarrhea (andlt;= 10 days). Results: Asymptomatic norovirus infections were observed in 11.7% (19/163), with children andlt;= 6 months of age being most frequently infected (16%). Of the 19 norovirus-positive children, 4 (21%) and 10 (53%) were infected with genogroups GI and GII, respectively, and 4 children (21%) were infected with viruses of both genogroups. Most children had andgt;= 10(6) viral genomes per gram of feces. Nucleotide sequence analysis (15/19) revealed uncommon genotypes, such as, GII. 7 (n = 5) and GII. 2 (n = 3). An interesting observation was the low frequency of norovirus GII. 4 strains among the asymptomatic children. AB blood type, Lewis a (Lea(a+b-)) phenotype and nonsecretor genotype (se(428)se(428)) were not found among the asymptomatic children, but they occurred in population controls. Conclusions: Frequency of asymptomatic norovirus infections was similar to that observed in symptomatic children from Nicaragua. Norovirus GII. 2 and GII. 7 were frequently detected but the globally dominating GII. 4 was infrequent. Host genetic factors previously observed to be associated with protection against symptomatic norovirus infection were not found in this study.

Ort, förlag, år, upplaga, sidor
Williams and Wilkins , 2010. Vol. 29, nr 10, s. 934-939
Nyckelord [en]
norovirus, asymptomatic, host genetic factors
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-60232DOI: 10.1097/INF.0b013e3181ed9f2fISI: 000282069700008OAI: oai:DiVA.org:liu-60232DiVA, id: diva2:355867
Tillgänglig från: 2010-10-08 Skapad: 2010-10-08 Senast uppdaterad: 2010-10-08

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Nordgren, JohanSvensson, Lennart

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