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Trigger finger and tendinosis
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Hand och plastikkirurgi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Ortopedi. Linköpings universitet, Hälsouniversitetet.
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Ortopedi. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Centrum för kirurgi, ortopedi och cancervård, Ortopedkliniken i Linköping.
2012 (Engelska)Ingår i: Journal of Hand Surgery, European Volume, ISSN 1753-1934, E-ISSN 2043-6289, Vol. 37, nr 3, s. 233-236Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The pathogenesis of trigger finger has generally been ascribed to primary changes in the pulley. Histological examination of the affected tendons has rarely been done. We studied biopsies from tendons of trigger fingers from 29 patients and compared these to biopsies from six intact tendons. We used a modified Movin score, which describes the tendinosis of the Achilles tendon. Trigger finger tendons had a high score (14.2; SD, 2.2) consistent with tendinosis, while the controls were almost normal (2.5; SD, 1.9). This suggests that the tendon is also affected, and that trigger finger is a form of tendinosis.

Ort, förlag, år, upplaga, sidor
Sage Publications, 2012. Vol. 37, nr 3, s. 233-236
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-76086DOI: 10.1177/1753193411421853ISI: 000300994100007PubMedID: 21987275OAI: oai:DiVA.org:liu-76086DiVA, id: diva2:512148
Tillgänglig från: 2012-03-26 Skapad: 2012-03-26 Senast uppdaterad: 2017-12-07Bibliografiskt granskad
Ingår i avhandling
1. Tendinosis in Trigger Finger
Öppna denna publikation i ny flik eller fönster >>Tendinosis in Trigger Finger
2017 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

Trigger finger is one of the most common hand conditions, with a prevalence of almost 3%. The aetiology remains unclear even though many causes have been suggested. The prevailing paradigm is that the pathogenesis of trigger finger is ascribed to primary changes in the first fibrous condensation of the tendon sheath (A1-pulley). Several studies have investigated pathology in the pulley, but few have investigated the tendon. The general aim of this thesis was to find out if there is pathology in the trigger finger tendon and to define it.

We first looked at trigger finger tendon biopsies in a light microscope, and found that they were histologically different from healthy tendons. They showed signs of micro-ruptures, collagen degradation, increased amounts of ground substance, both hyper- and hypo-cellular areas, round active cell nuclei and absence of inflammatory cells, all similar to tendinosis. The histological picture was further assessed by using a scoring system for Achilles tendinosis. The trigger finger tendons scored high, suggesting a similar histopathology.

Next, we performed a quantitative real-time polymerase chain reaction (qPCR) on trigger finger tendons. We assessed the mRNA expression of 10 genes, which have been described to be differently expressed in Achilles tendinosis (collagen 1 and 3, versican, decorin, biglycan, aggrecan, MMP-2, MMP-3, ADAMTS-5, and TIMP-3). The overall expression pattern agreed with previous studies on Achilles tendinosis, suggesting that the cellular function in trigger finger tendons is disturbed in a similar way as in Achilles tendinosis.

Recent experimental and observational research has suggested potential side effects of statin treatment on tendons, but firm evidence was lacking. We performed an epidemiological study on two large population-based cohorts. Statin use was found to increase the risk of both trigger finger and tendinosis in the shoulder and Achilles tendons, especially among men. This suggests a similar pathology in trigger finger and tendinosis.

We have also studied the time to treatment effect after a single injection of glucocorticoid in trigger finger. Our results suggest that 60-80% of patients can expect resolution of the triggering within 14 days, and half of them within seven days. This result allows correct information to be given to the patient and proper planning of follow-ups.

In conclusion, the pathology in trigger finger tendons is similar to tendinosis in other tendons.

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2017. s. 61
Serie
Linköping University Medical Dissertations, ISSN 0345-0082 ; 1573
Nationell ämneskategori
Gastroenterologi Neurologi Hematologi Annan klinisk medicin Klinisk laboratoriemedicin
Identifikatorer
urn:nbn:se:liu:diva-136784 (URN)10.3384/diss.diva-136784 (DOI)9789176855355 (ISBN)
Disputation
2017-06-07, Granitsalen, Universitetssjukhuset, Linköping, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2017-04-25 Skapad: 2017-04-25 Senast uppdaterad: 2017-05-09Bibliografiskt granskad

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Lundin, Anna-CarinEliasson, PernillaAspenberg, Per

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Lundin, Anna-CarinEliasson, PernillaAspenberg, Per
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Hand och plastikkirurgiHälsouniversitetetOrtopediOrtopedkliniken i Linköping
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Journal of Hand Surgery, European Volume
Medicin och hälsovetenskap

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