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Limited effect on NS3-NS4A protein cleavage after alanine substitutions within the immunodominant HLA-A2-restricted epitope of the hepatitis C virus genotype 3a non-structural 3/4A protease
Karolinska University Hospital Huddinge, Sweden .
Karolinska University Hospital Huddinge, Sweden .
University of Coll Dublin, Ireland .
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet.
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2012 (Engelska)Ingår i: Journal of General Virology, ISSN 0022-1317, E-ISSN 1465-2099, Vol. 93, s. 1680-1686Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

It has been well established that immunological escape mutations within the hepatitis C virus genotype (gt) la non-structural (NS) 3/4A protease are partly prevented by a reduction in viral protease fitness. Surprisingly little is known about whether similar mutations affect proteases from other genotypes. In the present study, we assessed both the HLA-A2-restricted CTL response and gt3a NS3/4A protease fitness. Similar to gt1, the 1073-1081 epitope was immunodominant within the gt3a-specific HLA-A2-restricted CTL response, despite sequence similarity of only 56% between the gt1a and gt3a genes. However, unlike the gt1a NS3/4A protease, all residues within the gt3a 1073-1081 epitope could be replaced sequentially by alanine while retaining protease activity, at least in part.

Ort, förlag, år, upplaga, sidor
Society for General Microbiology , 2012. Vol. 93, s. 1680-1686
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Medicin och hälsovetenskap
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URN: urn:nbn:se:liu:diva-81827DOI: 10.1099/vir.0.043745-0ISI: 000307746100007OAI: oai:DiVA.org:liu-81827DiVA, id: diva2:556604
Anmärkning

Funding Agencies|Swedish Science Council||Swedish Cancer Society||Vinnova||Goljes Memorial Fund||Karolinska Institutet/Sodertorns University||Swedish Research Council|K2012-99X-22017-01-3|Swedish Society of Medicine||Ake Wiberg Foundation||Royal Swedish Academy of Sciences||Ruth and Richard Juhlin Foundation||Karolinska Institutet||Wilhelm and Martina Lundgren Foundation||

Tillgänglig från: 2012-09-25 Skapad: 2012-09-24 Senast uppdaterad: 2017-12-07

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