liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Secular Trends in Nosocomial Bloodstream Infections: Antibiotic-Resistant Bacteria Increase the Total Burden of Infection
University of Medical Centre Utrecht, Netherlands.
Geneva University Hospital and Medical Sch, Switzerland.
John Radcliffe Hospital, England.
Amphia Hospital, Netherlands.
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: Clinical Infectious Diseases, ISSN 1058-4838, E-ISSN 1537-6591, Vol. 56, nr 6, s. 798-805Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background. It is unknown whether rising incidence rates of nosocomial bloodstream infections (BSIs) caused by antibiotic-resistant bacteria (ARB) replace antibiotic-susceptible bacteria (ASB), leaving the total BSI rate unaffected.

Methods. We investigated temporal trends in annual incidence densities (events per 100 000 patient-days) of nosocomial BSIs caused by methicillin-resistant Staphylococcus aureus (MRSA), ARB other than MRSA, and ASB in 7 ARB-endemic and 7 ARB-nonendemic hospitals between 1998 and 2007.

Results. 33 130 nosocomial BSIs (14% caused by ARB) yielded 36 679 microorganisms. From 1998 to 2007, the MRSA incidence density increased from 0.2 to 0.7 (annual increase, 22%) in ARB-nonendemic hospitals, and from 3.1 to 11.7 (annual increase, 10%) in ARB-endemic hospitals (P = .2), increasing the incidence density difference between ARB-endemic and ARB-nonendemic hospitals from 2.9 to 11.0. The non-MRSA ARB incidence density increased from 2.8 to 4.1 (annual increase, 5%) in ARB-nonendemic hospitals, and from 1.5 to 17.4 (annual increase, 22%) in ARB-endemic hospitals (P < .001), changing the incidence density difference from −1.3 to 13.3. Trends in ASB incidence densities were similar in both groups (P = .7). With annual increases of 3.8% and 5.4% of all nosocomial BSIs in ARB-nonendemic and ARB-endemic hospitals, respectively (P < .001), the overall incidence density difference of 3.8 increased to 24.4.

Conclusions.  Increased nosocomial BSI rates due to ARB occur in addition to infections caused by ASB, increasing the total burden of disease. Hospitals with high ARB infection rates in 2005 had an excess burden of BSI of 20.6 per 100 000 patient-days in a 10-year period, mainly caused by infections with ARB.

Ort, förlag, år, upplaga, sidor
Oxford University Press (OUP): Policy A1 , 2013. Vol. 56, nr 6, s. 798-805
Nyckelord [en]
Trends, nosocomial, bloodstream infections, antibiotic-resistant bacteria, antibiotic-susceptible bacteria
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-90751DOI: 10.1093/cid/cis1006ISI: 000315630800012PubMedID: 23223600OAI: oai:DiVA.org:liu-90751DiVA, id: diva2:614703
Anmärkning

Funding Agencies|Netherlands Organization of Scientific Research|VICI NWO 918.76.611|Oxford National Institute for Health Research Biomedical Research Centre||Novartis||3M||Roche||Optimer Pharmaceuticals||Cepheid||bioMerieux||Astellas||Basilea||Bayer||Pfizer||Gilead||MSD||Oxoid||Wyeth||Siemens||Bruker||

Tillgänglig från: 2013-04-05 Skapad: 2013-04-05 Senast uppdaterad: 2017-12-06Bibliografiskt granskad

Open Access i DiVA

fulltext(630 kB)400 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 630 kBChecksumma SHA-512
af4cc2a52b9fc25ce0d20e2ac01ca6af05d9730715cc337d4116e4de364c16cab234d742d0ac4947c49fb579f879321ebad0dff72460a164507e6eae8c3ebfab
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Hanberger, Håkan

Sök vidare i DiVA

Av författaren/redaktören
Hanberger, Håkan
Av organisationen
InfektionsmedicinHälsouniversitetetInfektionskliniken i Östergötland
I samma tidskrift
Clinical Infectious Diseases
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 400 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 480 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf