liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Serum thymidine kinase activity compared with CA 15-3 in locally advanced and metastatic breast cancer within a randomized trial
Karolinska Institute, Sweden .
Karolinska Institute, Sweden .
Biov Int AB, Sweden .
Karolinska Institute, Sweden .
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: Breast Cancer Research and Treatment, ISSN 0167-6806, E-ISSN 1573-7217, Vol. 139, nr 3, s. 751-758Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The primary objective was to estimate serum thymidine kinase 1 (TK1) activity, reflecting total body cell proliferation rate including cancer cell proliferation, in women with loco regional inoperable or metastatic breast cancer participating in a prospective and randomized study. Secondary objectives were to analyze TK1 in relation to progression-free survival (PFS), overall survival (OS), therapy response and other tumour characteristics, including CA 15-3, widely used as a standard serum marker for disease progression. TK1 and CA 15-3 were analysed in 198 serum samples collected prospectively from women included in the randomized TEX trial between December 2002 and June 2007. TK1 activity was determined by the ELISA based DiviTum (TM) assay, and CA 15-3 analyses was generated with the electrochemiluminescence immunoassay Cobas Elecsys CA 15-3 II. High pre-treatment TK1 activity predicted shorter PFS (10 vs. 15 months p = 0.02) and OS (21 vs. 38 months, p andlt; 0.0001), respectively. After adjustment for age, metastatic site and study treatment TK1 showed a trend as predictor of PFS (p = 0.059) and was an independent prognostic factor for OS, (HR 1.81, 95 % confidence interval (CI) 1.26-2.61, p = 0.001). There was a trend of shortened OS for women with high CA 15-3 (p = 0.054) in univariate analysis, but not after adjustment for the above mentioned covariates. Both TK1 (p = 0.0011) and CA 15-3 (p = 0.0004) predicted response to treatment. There were statistically different distributions of TK1 and CA 15-3 in relation to the site of metastases. TK1 activity measured by DiviTum (TM) predicted therapy response, PFS and OS in loco regional inoperable or disseminated breast cancer. These results suggest that this factor is a useful serum marker. In the present material, a prognostic value of CA 15-3 could not be proven.

Ort, förlag, år, upplaga, sidor
Springer Verlag (Germany) , 2013. Vol. 139, nr 3, s. 751-758
Nyckelord [en]
TK1, CA 15-3, Breast cancer, Prognostic factor, Predictive factor, DiviTum
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-95969DOI: 10.1007/s10549-013-2579-xISI: 000321070200012OAI: oai:DiVA.org:liu-95969DiVA, id: diva2:641642
Anmärkning

Funding Agencies|Swedish Cancer Society||Stockholm Cancer Society||King Gustav V Jubilee Fund||Swedish Research Council||Stockholm City Council||Karolinska Institutet||Stockholm County Council Research Strategy Committee||BRECT||Swedish Breast Cancer Association||Marit and Hans Rausings Initiative Against Breast Cancer||Karolinska Institutet Research Funds||Biovica International AB||

Tillgänglig från: 2013-08-19 Skapad: 2013-08-12 Senast uppdaterad: 2017-12-06

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltext

Person

Walz, Thomas

Sök vidare i DiVA

Av författaren/redaktören
Walz, Thomas
Av organisationen
Avdelningen för kliniska vetenskaperHälsouniversitetetOnkologiska kliniken US
I samma tidskrift
Breast Cancer Research and Treatment
Medicin och hälsovetenskap

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetricpoäng

doi
urn-nbn
Totalt: 217 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf