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Possible transmission of Candida albicans on an intensive care unit: genotype and temporal cluster analyses
Ryhov County Hospital, Sweden .
Ryhov County Hospital, Sweden .
Ryhov County Hospital, Sweden .
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Thorax-kärlkliniken i Östergötland.
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2013 (Engelska)Ingår i: Journal of Hospital Infection, ISSN 0195-6701, E-ISSN 1532-2939, Vol. 85, nr 1, s. 60-65Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background: Nosocomial transmission of Candida spp. has not been fully explored and previous studies have shown conflicting results. less thanbrgreater than less thanbrgreater thanAim: To evaluate the possible nosocomial transmission of Candida spp. on an intensive care unit (ICU). less thanbrgreater than less thanbrgreater thanMethods: A prospective study was conducted for a period of 19 months, including all patients on our ICU with growth of Candida spp. from surveillance and directed cultures. Molecular typing with repetitive sequence-based polymerase chain reaction was used to define genotype relationships between the Candida albicans and Candida glabrata isolates. Candida isolates obtained from blood cultures taken from patients in our county outside the ICU were used as a reference. Temporal cluster analysis was performed to evaluate genotype distribution over time. less thanbrgreater than less thanbrgreater thanFindings: Seventy-seven patients with 78 ICU stays, representing 12% of all ICU stays, were found to harbour 180 isolates of Candida spp. Molecular typing revealed 27 C. albicans genotypes and 10 of C. glabrata. Possible clustering, indicated by overlapping stays of patients with indistinguishable candida genotypes, was observed on seven occasions with C. albicans and on two occasions with C. glabrata. Two C. albicans genotypes were found significantly more often in the ICU group compared with the reference group. Moreover, C. albicans genotypes isolated from more than one patient were significantly more often found in the ICU group. Temporal cluster analysis revealed a significantly increased number of pairs with indistinguishable genotypes at a 21-day interval, indicating clustering. less thanbrgreater than less thanbrgreater thanConclusion: This study indicates possible transmission of C. albicans between ICU patients based on genotyping and temporal cluster analysis.

Ort, förlag, år, upplaga, sidor
WB Saunders , 2013. Vol. 85, nr 1, s. 60-65
Nyckelord [en]
Candida, Intensive care unit, Molecular typing, Nosocomial infections
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-97656DOI: 10.1016/j.jhin.2013.06.002ISI: 000323707400009OAI: oai:DiVA.org:liu-97656DiVA, id: diva2:649994
Anmärkning

Funding Agencies|Futurum the Academy for Health-care, Jonkoping County Council, Jonkoping, Sweden||

Tillgänglig från: 2013-09-19 Skapad: 2013-09-19 Senast uppdaterad: 2017-12-06

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Berg, SörenHanberger, HåkanMalmvall, Bo-Eric

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Berg, SörenHanberger, HåkanMalmvall, Bo-Eric
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Avdelningen för kardiovaskulär medicinHälsouniversitetetThorax-kärlkliniken i ÖstergötlandAvdelningen för mikrobiologi och molekylär medicinInfektionskliniken i ÖstergötlandInfektionsmedicin
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Journal of Hospital Infection
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