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Electroresponsive Nanoporous Membranes by Coating Anodized Alumina with Poly(3,4-ethylenedioxythiophone) and Polypyrrole
University of Utah, Salt Lake City, USA.
Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.
Linköpings universitet, Institutionen för fysik, kemi och biologi, Biosensorer och bioelektronik. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0002-2071-7768
Linköpings universitet, Institutionen för teknik och naturvetenskap. Linköpings universitet, Tekniska högskolan.ORCID-id: 0000-0001-5154-0291
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2014 (Engelska)Ingår i: Macromolecular materials and engineering (Print), ISSN 1438-7492, E-ISSN 1439-2054, Vol. 299, nr 2, s. 190-197Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Electrically-active nanoporous membranes are prepared by coating the surface of anodized alumina with electroactive polymers using vapor phase polymerization with four combinations of conjugated polymers and doping ions: poly(3,4-ethylenedioxythiophone) and polypyrrole, FeCl3 and FeTs3. The permeability of the polymer-coated membranes is measured as a function of the applied electric potential. A reversible three-fold increase is found in molecular flux of a neutral dye for membranes in oxidized state compared to that in the reduced state. After analyzing various factors that may affect the molecular transport through these membranes, it is concluded that the observed behavior results mostly from swelling/deswelling of the polymers and from the confinement of the polymers inside the nanopores.

Ort, förlag, år, upplaga, sidor
Wiley-VCH Verlagsgesellschaft, 2014. Vol. 299, nr 2, s. 190-197
Nyckelord [en]
electroresponsive; membrane; nanopore; vapor phase polymerization
Nationell ämneskategori
Materialteknik
Identifikatorer
URN: urn:nbn:se:liu:diva-103014DOI: 10.1002/mame.201200456ISI: 000336481500006OAI: oai:DiVA.org:liu-103014DiVA, id: diva2:685378
Tillgänglig från: 2014-01-09 Skapad: 2014-01-09 Senast uppdaterad: 2017-12-06
Ingår i avhandling
1. Electronic Control of Cell Cultures Using Conjugated Polymer Surfaces
Öppna denna publikation i ny flik eller fönster >>Electronic Control of Cell Cultures Using Conjugated Polymer Surfaces
2014 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

In the field of bioelectronics various electronic materials and devices are used in combination with biological systems in order to create novel applications within cell biology and medicine. A famous example of a successful bioelectronics application is the pacemaker. Metals are the most common electrical conductors, whereas polymers are generally considered being insulators. However, in the late 1970s it was shown that a special class of polymers with conjugated double bonds, could in fact, after some chemical modifications, conduct electricity. This was the start of the research field known as conducting polymers, and then later on organic electronics, a research area that has grown rapidly during the last decades. Conjugated polymers are also suitable to interact and interface with cells and tissues, as they are generally soft, flexible and biocompatible. In addition, their chemical properties can be tailor-made through synthesis to fit biological requirements and functions. During the last years applications using organic bioelectronics have become numerous.

This thesis describes applications based on different conjugated polymers aiming to stimulate and control cell cultures. When culturing cells it is of interest to be able to control events such as adhesion, spreading, proliferation, differentiation and detachment. First, the impact of different polymer compositions and redox states on the adhesion of bacteria and subsequent biofilm formation was investigated. Similar polymer electrodes were also used to steer differentiation of neural stem cells, through changes in the surface exposure of a relevant biomolecule. Controlled delivery of molecules was achieved by coating nanoporous membranes with polymers that swell and contract when changing the redox state. Finally, electronic control over cell detachment using a water-soluble polymer was achieved. When applying a positive potential to this polymer, it swells, cracks and finally detaches, taking the cells that was cultured on top along with it. Together, the work and results presented in this thesis demonstrate a versatile conjugated polymer technology to achieve electronic control of the different growth stages of cell cultures as well as cellular functions.

Ort, förlag, år, upplaga, sidor
Linköping: Linköping University Electronic Press, 2014. s. 64
Serie
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1594
Nationell ämneskategori
Naturvetenskap
Identifikatorer
urn:nbn:se:liu:diva-106254 (URN)10.3384/diss.diva-106254 (DOI)978-91-7519-340-3 (ISBN)
Disputation
2014-05-23, K2, Kåkenhus, Campus Valla, Linköpings universitet, Linköping, 10:15 (Engelska)
Opponent
Handledare
Tillgänglig från: 2014-04-30 Skapad: 2014-04-30 Senast uppdaterad: 2017-02-03Bibliografiskt granskad

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Persson, KristinJager, EdwinBerggren, Magnus

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Macromolecular materials and engineering (Print)
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