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Analysis of single nucleotide polymorphisms in the region of CLDN2-MORC4 in relation to inflammatory bowel disease
Ryhov County Hospital, Sweden .
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet. Ryhov County Hospital, Sweden.
Ryhov County Hospital, Sweden .
Ryhov County Hospital, Sweden .
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2013 (Engelska)Ingår i: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 19, nr 30, s. 4935-4943Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

AIM: To investigate a possible genetic influence of claudin (CLDN) 1, CLDN2 and CLDN4 in the etiology of inflammatory bowel disease. METHODS: Allelic association between genetic regions of CLDN1, CLDN2 or CLDN4 and patients with inflammatory bowel disease, Crohns disease (CD) or ulcerative colitis were investigated using both a case-control study approach (one case randomly selected from each of 191 Swedish inflammatory bowel disease families and 333 controls) and a family-based study (463 non-Swedish European inflammatory bowel disease-families). A nonsynonymous coding single nucleotide polymorphism in MORC4, located on the same linkage block as CLDN2, was investigated for association, as were two novel CLDN2 single nucleotide polymorphism markers, identified by resequencing. RESULTS: A single nucleotide polymorphism marker (rs12014762) located in the genetic region of CLDN2 was significantly associated to CD (case-control allelic OR = 1.98, 95% CI: 1.17-3.35, P = 0.007). MORC4 was present on the same linkage block as this CD marker. Using the case-control approach, a significant association (case control allelic OR = 1.61, 95% CI: 1.08-2.41, P = 0.018) was found between CD and a nonsynonymous coding single nucleotide polymorphism (rs6622126) in MORC4. The association between the CLDN2 marker and CD was not replicated in the family-based study. Ulcerative colitis was not associated to any of the single nucleotide polymorphism markers. CONCLUSION: These findings suggest that a variant of the CLDN2-MORC4 region predisposes to CD in a Swedish population.

Ort, förlag, år, upplaga, sidor
BAISHIDENG PUBL GRP CO LTD , 2013. Vol. 19, nr 30, s. 4935-4943
Nyckelord [en]
Crohns disease; Genetic predisposition; Inflammatory bowel disease; Single nucleotide polymorphism; Tight junctions
Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
URN: urn:nbn:se:liu:diva-103408DOI: 10.3748/wjg.v19.i30.4935ISI: 000323326700011OAI: oai:DiVA.org:liu-103408DiVA, id: diva2:689064
Tillgänglig från: 2014-01-20 Skapad: 2014-01-20 Senast uppdaterad: 2019-04-03

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Bragde, HannaAlmer, Sven

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Institutionen för klinisk och experimentell medicinHälsouniversitetetAvdelningen för inflammationsmedicinMagtarmmedicinska kliniken
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