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Conditioned Preference to a Methamphetamine-Associated Contextual Cue in Humans
University of Chicago, IL 60637 USA .
Linköpings universitet, Institutionen för klinisk och experimentell medicin. Linköpings universitet, Hälsouniversitetet. NIAAA, MD 20892 USA .
University of Chicago, IL 60637 USA .
NIAAA, MD 20892 USA .
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2013 (Engelska)Ingår i: Neuropsychopharmacology, ISSN 0893-133X, E-ISSN 1740-634X, Vol. 38, nr 6, s. 921-929Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Classical conditioning is widely used to study motivational properties of addictive drugs in animals, but has rarely been used in humans. We established a procedure suitable for studying the neurobiology and individual determinants of classical conditioning in humans. Healthy volunteers were randomly assigned to four groups that received methamphetamine or placebo in the presence of distinctive environmental cues under paired or unpaired conditions. During each session, subjects performed tasks known to activate the ventral striatum. Tasks were performed in the presence of a distinctive context, consisting of a screen background image of a beach or mountains, accompanied by corresponding sounds. Separate groups of subjects carried out the tasks under high ($35-50) or low ($5-20) reward conditions. Within each of the two reward conditions, one group (paired) received methamphetamine (20 mg, oral) or placebo consistently associated with one of the contexts, while the other (unpaired) received drug or placebo unrelated to context. A fifth group (paired) performed the tasks with contextual cues but in the absence of monetary incentives. Before and after conditioning, participants carried out a series of forced choice tasks for the contextual cues, and change of preference over time was analyzed. All paired groups showed a significant increase in preference for the drug-associated context, with a linear trend for increase across the levels of reward. Preference was unrelated to subjective drug effects, and did not change in the unpaired group. These data support the translational utility of our conditioning procedure for studies of reward mechanisms in humans.

Ort, förlag, år, upplaga, sidor
Nature Publishing Group: Open Access Hybrid Model Option A , 2013. Vol. 38, nr 6, s. 921-929
Nyckelord [en]
conditioning, place preference, stimulant, amphetamine, reward
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URN: urn:nbn:se:liu:diva-103400DOI: 10.1038/npp.2013.3ISI: 000317584600002OAI: oai:DiVA.org:liu-103400DiVA, id: diva2:689077
Anmärkning

Funding Agencies|Division of Intramural Clinical and Biological Research NIAAA||Unilever|||DA02812||T32 DA007255|

Tillgänglig från: 2014-01-20 Skapad: 2014-01-20 Senast uppdaterad: 2017-12-06

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