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Low gut microbiota diversity in early infancy precedes asthma at school age
Linköpings universitet, Institutionen för klinisk och experimentell medicin, Avdelningen för kliniska vetenskaper. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Barn- och kvinnocentrum, Barn- och ungdomskliniken i Linköping.
Karolinska Institute, Stockholm, Sweden.
KTH Royal Institute of Technology, Stockholm, Sweden.
Karolinska Institute, Stockholm, Sweden; Örebro University, Sweden .
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2014 (Engelska)Ingår i: Clinical and Experimental Allergy, ISSN 0954-7894, E-ISSN 1365-2222, Vol. 44, nr 6, s. 842-850Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

BACKGROUND:

Low total diversity of the gut microbiota during the first year of life is associated with allergic diseases in infancy, but little is known how early microbial diversity is related to allergic disease later in school age.

OBJECTIVE:

To assess microbial diversity and characterize the dominant bacteria in stool during the first year of life in relation to the prevalence of different allergic diseases in school age, such as asthma, allergic rhinoconjunctivitis (ARC) and eczema.

METHODS:

The microbial diversity and composition was analysed with barcoded 16S rDNA 454 pyrosequencing in stool samples at 1 week, 1 month and 12 months of age in 47 infants which were subsequently assessed for allergic disease and skin prick test reactivity at 7 years of age (ClinicalTrials.gov ID NCT01285830).

RESULTS:

Children developing asthma (n = 8) had a lower diversity of the total microbiota than non-asthmatic children at 1 week (P = 0.04) and 1 month (P = 0.003) of age, whereas allergic rhinoconjunctivitis (n = 13), eczema (n = 12) and positive skin prick reactivity (n = 14) at 7 years of age did not associate with the gut microbiota diversity. Neither was asthma associated with the microbiota composition later in infancy (at 12 months). Children having IgE-associated eczema in infancy and subsequently developing asthma had lower microbial diversity than those that did not. There were no significant differences, however, in relative abundance of bacterial phyla and genera between children with or without allergic disease.

CONCLUSION AND CLINICAL RELEVANCE:

Low total diversity of the gut microbiota during the first month of life was associated with asthma but not ARC in children at 7 years of age. Measures affecting microbial colonization of the infant during the first month of life may impact asthma development in childhood.

Ort, förlag, år, upplaga, sidor
Wiley-Blackwell, 2014. Vol. 44, nr 6, s. 842-850
Nyckelord [en]
asthma; allergic rhinoconjunctivitis; birth; children; diversity; hygiene hypothesis; microbiota; molecular microbiology
Nationell ämneskategori
Klinisk medicin Cell- och molekylärbiologi Mikrobiologi inom det medicinska området
Identifikatorer
URN: urn:nbn:se:liu:diva-109137DOI: 10.1111/cea.12253ISI: 000337529100006PubMedID: 24330256OAI: oai:DiVA.org:liu-109137DiVA, id: diva2:737516
Tillgänglig från: 2014-08-13 Skapad: 2014-08-11 Senast uppdaterad: 2018-01-11Bibliografiskt granskad

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Abrahamsson, ThomasJenmalm, Maria

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Avdelningen för kliniska vetenskaperHälsouniversitetetBarn- och ungdomskliniken i LinköpingAvdelningen för inflammationsmedicin
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