Urine osmolality estimated using urine urea nitrogen, sodium and creatinine can effectively predict response to tolvaptan in decompensated heart failure patientsVisa övriga samt affilieringar
2013 (Engelska)Ingår i: Circulation Journal, ISSN 1346-9843, E-ISSN 1347-4820, Vol. 77, nr 5, s. 1208-1213Artikel i tidskrift (Refereegranskat) Published
Abstract [en]
BACKGROUND:
Urine osmolality (U-OSM) is valuable to predict response to tolvaptan (TLV) in decompensated heart failure patients, but measurement of U-OSM is not always available on site.
METHODS AND RESULTS:
Data were collected from 66 hospitalized patients with decompensated heart failure who had received TLV at 3.75-15 mg/day. U-OSM, which was estimated using the following formula: 1.07×{2×[(urine sodium (mEq/L)]+[urine urea nitrogen (mg/dl)]/2.8+[urine creatinine (mg/dl)]×2/3}+16, was well correlated with the actual measurement (r=0.938, P<0.001). Criteria consisting of C1 (estimated baseline U-OSM>358 mOsm/L) and C2 (%decrease in estimated U-OSM>24% at 4-6 h after the first TLV dose) significantly discriminated responders from non-responders (P<0.05).
CONCLUSIONS:
Response to TLV can be predicted using U-OSM, which can be estimated using urine urea nitrogen, sodium, and creatinine concentration data.
Ort, förlag, år, upplaga, sidor
Japanese Circulation Society , 2013. Vol. 77, nr 5, s. 1208-1213
Nyckelord [en]
Hyponatremia; Responder; Vasopressin
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
URN: urn:nbn:se:liu:diva-111184DOI: 10.1253/circj.CJ-12-1328ISI: 000318320000020PubMedID: 23318562OAI: oai:DiVA.org:liu-111184DiVA, id: diva2:754522
Anmärkning
Funding Agencies|Japan Society for the Promotion of Science [224943]; Japanese Heart Foundation; Japanese Association for Cerebro-Cardiovascular Disease Control; AstraZeneca; Pfizer Health Research Foundation
2014-10-102014-10-102020-01-13Bibliografiskt granskad