liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Acute pulmonary vasoreactivity test with sildenafil or nitric monoxide before left ventricular assist device implantation
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .
University of Tokyo, Japan .ORCID-id: 0000-0002-4437-0260
Visa övriga samt affilieringar
2013 (Engelska)Ingår i: Journal of Artificial Organs, ISSN 1434-7229, E-ISSN 1619-0904, Vol. 16, nr 3, s. 389-392Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

There has been no established medical therapy to ameliorate pulmonary hypertension (PH) owing to left heart disease (LHD-PH). It has recently been shown that the left ventricular assist device (LVAD) can improve LHD-PH and therefore has the potential to become a major bridge tool for heart transplantation (HTx). However, some patients still have persistent PH even after LVAD treatment. It is essential to demonstrate the reversibility of end-organ dysfunction, including PH, prior to implantable LVAD treatment, especially in Japan, because implantable LVAD treatment is indicated only as bridge to transplantation. Here we report a patient with LHD-PH whose PH was demonstrated to be reversible by the acute pulmonary vasoreactivity test (APVT) with nitrogen monoxide (NO) and the phosphodiesterase-5 inhibitor sildenafil. Both inhaled NO and sildenafil reduced pulmonary vascular resistance, but pulmonary capillary wedge pressure was increased by NO, which was conversely decreased under increased cardiac output by sildenafil. After the patient was listed as an HTx recipient, pulmonary vascular resistance recovered down to an acceptable range with LVAD treatment. Based on these findings, we suggest that the APVT with sildenafil may be a useful and safe tool to predict improvement of PH after LVAD treatment.

Ort, förlag, år, upplaga, sidor
Springer Verlag (Germany) , 2013. Vol. 16, nr 3, s. 389-392
Nyckelord [en]
Heart failure; Transplantation; Pulmonary hypertension; Out of proportion
Nationell ämneskategori
Hälsovetenskaper
Identifikatorer
URN: urn:nbn:se:liu:diva-111181DOI: 10.1007/s10047-013-0706-4ISI: 000325183500016PubMedID: 23559349OAI: oai:DiVA.org:liu-111181DiVA, id: diva2:754531
Tillgänglig från: 2014-10-10 Skapad: 2014-10-10 Senast uppdaterad: 2019-03-29

Open Access i DiVA

Fulltext saknas i DiVA

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Kato, Naoko

Sök vidare i DiVA

Av författaren/redaktören
Kato, Naoko
I samma tidskrift
Journal of Artificial Organs
Hälsovetenskaper

Sök vidare utanför DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 76 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf