liu.seSök publikationer i DiVA
Ändra sökning
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Selenium and coenzyme Q10 interrelationship in cardiovascular diseases - A clinician's point of view
Linköpings universitet, Institutionen för medicin och hälsa, Avdelningen för kardiovaskulär medicin. Linköpings universitet, Hälsouniversitetet. Östergötlands Läns Landsting, Hjärt- och Medicincentrum, Kardiologiska kliniken US.
Innlandet Hospital Trust, N-2226 Kongsvinger, Norway.
2015 (Engelska)Ingår i: Journal of Trace Elements in Medicine and Biology, ISSN 0946-672X, E-ISSN 1878-3252, Vol. 31, s. 157-162Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A short review is given of the potential role of selenium deficiency and selenium intervention trials in atherosclerotic heart disease. Selenium is an essential constituent of several proteins, including the glutathione peroxidases and selenoprotein P. The selenium intake in Europe is generally in the lower margin of recommendations from authorities. Segments of populations in Europe may thus have a deficient intake that may be presented by a deficient anti-oxidative capacity in various illnesses, in particular atherosclerotic disease, and this may influence the prognosis of the disease. Ischemic heart disease and heart failure are two conditions where increased oxidative stress has been convincingly demonstrated. Some of the intervention studies of anti-oxidative substances that have focused on selenium are discussed in this review. The interrelationship between selenium and coenzyme Q10, another anti-oxidant, is presented, pointing to a theoretical advantage in using both substances in an intervention if there are deficiencies within the population. Clinical results from an intervention study using both selenium and coenzyme Q10 in an elderly population are discussed, where reduction in cardiovascular mortality, a better cardiac function according to echocardiography, and finally a lower concentration of the biomarker NT-proBNP as a sign of lower myocardial wall tension could be seen in those on active treatment, compared to placebo.

Ort, förlag, år, upplaga, sidor
Elsevier, 2015. Vol. 31, s. 157-162
Nyckelord [en]
Coenzyme Q10; Oxidative stress; Selenium
Nationell ämneskategori
Klinisk medicin
Identifikatorer
URN: urn:nbn:se:liu:diva-113917DOI: 10.1016/j.jtemb.2014.11.006ISI: 000356192400024PubMedID: 25511910OAI: oai:DiVA.org:liu-113917DiVA, id: diva2:785624
Tillgänglig från: 2015-02-03 Skapad: 2015-02-03 Senast uppdaterad: 2017-12-05

Open Access i DiVA

fulltext(263 kB)555 nedladdningar
Filinformation
Filnamn FULLTEXT01.pdfFilstorlek 263 kBChecksumma SHA-512
bda8d4cf937a04ced42972313361658374402101f2ae0131df4e6a32405681c67ccd4bfce20a2f3ec0eed3ad6118dbe5253c0449e2e2d55225f48e4db76c5772
Typ fulltextMimetyp application/pdf

Övriga länkar

Förlagets fulltextPubMed

Personposter BETA

Alehagen, Urban

Sök vidare i DiVA

Av författaren/redaktören
Alehagen, Urban
Av organisationen
Avdelningen för kardiovaskulär medicinHälsouniversitetetKardiologiska kliniken US
I samma tidskrift
Journal of Trace Elements in Medicine and Biology
Klinisk medicin

Sök vidare utanför DiVA

GoogleGoogle Scholar
Totalt: 555 nedladdningar
Antalet nedladdningar är summan av nedladdningar för alla fulltexter. Det kan inkludera t.ex tidigare versioner som nu inte längre är tillgängliga.

doi
pubmed
urn-nbn

Altmetricpoäng

doi
pubmed
urn-nbn
Totalt: 501 träffar
RefereraExporteraLänk till posten
Permanent länk

Direktlänk
Referera
Referensformat
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Annat format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annat språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf